Associate Research Scientist, Peptide Chemistry - Cambridge, United Kingdom - Bicycle Therapeutics

Bicycle Therapeutics
Bicycle Therapeutics
Verified Company
Cambridge, United Kingdom

3 weeks ago

Tom O´Connor

Posted by:

Tom O´Connor

beBee Recruiter
Description
Company Description
Bicycle Therapeutics (


NASDAQ:
BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines.

Our pipeline includes Bicycle Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need.

Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

  • We are
    Adventurous. We believe it's the way to deliver extraordinary results for our patients.
  • We are
    Dedicated to our Mission. You can't change the world if you don't have determination.
  • We are
    One Team. We only succeed when we work together.

Job Description:


We have a new opportunity for an Associate Research Scientist, in the peptide purification chemistry team who will join a dynamic and fast-moving team and will be involved in the purification of peptides and Bicyclic peptides (Bicycles).

Working as part of the Discovery team you will be responsible for advancing early stage drug discovery projects from concept to molecule and for delivering peptides and reagents to the Discovery teams to help drive Structure Activity Relationship studies.

The role will involve close interaction with the Biology, Chemistry, DMPK and informatics teams to organise and schedule laboratory and project activities and to review data and progress.

Additional interactions will be with our US team and external collaborators in our partnership deals as appropriate.

You should be self-motivated, well organised, diligent in record keeping, have a good working knowledge of the drug discovery process and be able to perform consistently at the highest level.


Key responsibilities:


  • Purification of peptides and bicyclic Bicycles by HPLC
  • Use of a variety of analytical techniques (such as LC-MS, MALDI-TOF) to characterize Bicycles
  • Entry of peptides into databases and repositories, ensuring accurate record keeping and adhering to standard operating procedures
  • A range of standard lab procedures to support wet chemistry
  • Clear and accurate record keeping
Qualifications*Essential:
  • Graduate in Chemistry or related Chemical Science
  • Specific experience in the purification and analysis of peptides using reversephase HPLC.
  • Continuous development of more robust problem solving skills
  • Strong interpersonal skills and effective interaction with other teams
  • Consistent team player with good communication skills
  • Good organisational skills and close attention to detail
  • Confident with requirements of data integrity and use of Electronic Lab Notebooks
  • Good time management skills and ability to work to tight deadlines
  • Innovative, entrepreneurial, enjoys working in a fastpaced environment

Desirable:


  • Experience in the maintenance and upkeep of HPLC and LCMS systems
  • Experience in the use, maintenance and upkeep of Mass spectroscopy systems
  • Experience characterising peptides, proteins or large novel compounds using MS/MS spectroscopy
Additional Information

  • Stateoftheart campus environment
  • Competitive reward package
  • 28 days annual leave in addition to bank holidays, plus option to buy up to 5 additional days
  • Employer contribution to pension
  • Life assurance cover 4x basic salary
  • Private Medical Insurance, including optical and dental cover
  • Health Cash Plan
  • Cycle to work scheme
  • Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status._
More jobs from Bicycle Therapeutics
See all jobs of Bicycle Therapeutics