Research Associate in Structural Biology of - Manchester, United Kingdom - The University of Manchester

The University of Manchester

Verified Company

Manchester, United Kingdom

3 weeks ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

Based on the laboratory of Dr.

Christos Pliotas, you will work on an exciting project to understand the structure and function of integral membrane proteins, in particular mechanosensitive ion channels.

These systems form pores in the cell membrane and allow the passage of molecules in response to membrane tension.

A multi-disciplinary approach combining molecular biology, structural biology (cryoEM and pulsed Electron Paramagnetic Resonance (EPR), or PELDOR/DEER spectroscopy), along with computational method (MD simulations) will be employed to investigate gating and regulation of these novel ion channels and characterise their unique states.

We are seeking an individual with a strong basis in molecular and structural biology, and substantial experience in working with integral membrane proteins.

You should have a PhD (or be close to completion) or equivalent in Molecular Biology, Structural Biology, Biochemistry or a closely allied discipline and have previous experience in eukaryotic membrane protein expression, purification, spin labelling and/or PELDOR spectroscopy, molecular dynamics simulations would be desirable.

The full-time position is available from 01 April 2023 for a fix-term for 12 months.

Our University is positive about flexible working - you can find out more here

Blended working arrangements may be considered

Enquiries about the vacancy, shortlisting and interviews:

Name:
Christos Pliotas

General enquiries:

Technical support:

**Please see the link below for the Further Particulars document which contains the person specification criteria.