Jamie Thomas

Innovative molecular biologist specialising in translational research for vaccine development. Proven ability to design, execute and optimise experiments using mass spectrometry, immunostaining and bioinformatics. Experienced in GLP-compliant environments, working on cross-functional teams to accelerate drug discovery and vaccine pipelines. Passionate about applying cutting-edge research to develop novel biotechnological solutions.

A highly skilled Molecular Biologist specialising in translational research for vaccine development, with extensive experience in mass spectrometry, immunostaining, and bioinformatics. 

Expertise includes designing, executing, and optimising experiments in GLP-compliant environments, contributing to biomarker discovery and vaccine pipelines in cross-functional teams. Proficient in molecular and cell biology techniques such as mammalian cell culture, flow cytometry, Western blotting, ELISA, PCR/qPCR, and immunofluorescence microscopy. Strong background in regulatory compliance, including GLP, Data Integrity standards, biosafety regulations, and ethical publishing guidelines. 

Experience includes optimising biomarker workflows to improve identification and analysis in vaccine development. Additionally, skilled in peptide purification, refining immunoprecipitation techniques and sample preparation to enhance target peptide yield. Expertise in vaccine formulation, focusing on buffer optimisation and excipient selection to improve immunogenicity and stability. 

Further experience includes managing peer review processes to ensure regulatory integrity in biomedical research. Also proficient in evaluating clinical grant applications, assessing translational research for biotech and pharmaceutical stakeholders. Additionally, responsible for leading editorial training programs in scientific publishing, improving quality control processes and compliance with industry standards. 

Previous research involvement includes developing B-cell and T-cell functionality assays, optimising flow cytometry sorting techniques, and overseeing laboratory management. Skilled in bioinformatics and data analysis, with proficiency in R, Python, and MATLAB, as well as specialised software for flow cytometry, mass spectrometry, and statistical analysis. With a strong interdisciplinary background in cancer research, immunology, and vaccine development.

Holds a PhD in Biological Sciences with a strong focus on melanoma proteomics and cancer vaccine development. Research involved mass spectrometry-based quantification of the melanoma proteome, identifying protein-protein interactions and post-translational modifications in tumor-associated antigens to advance cancer immunotherapy. Experimental validation techniques included immunofluorescence microscopy, immunoprecipitation, Western blotting, ELISPOT, and ELISA to assess immunogenicity and therapeutic potential.

 Also earned a First-Class MSci in Biomedical Sciences, specialising in immunology, medical biotechnology, and bioinformatics, with a dissertation on immune checkpoint responses in cancer.