Research Associate - Hammersmith, United Kingdom - Imperial College London

Tom O´Connor

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Tom O´Connor

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Description
We focus on the role of key neural-circuit plasticity processes thought to be critical for healthy network function.

To achieve this, we use preclinical mouse models and cutting-edge technologies including 1- and 2-Photon in vivo microscopy, electrophysiology, automated behavioural testing, single cell/nuclei transcriptomics, non-invasive brain stimulation, Imaging Mass Cytometry and computational modelling.

As a Research Associate in the lab, you will join a collaborative and highly skilled team.

You will take a leading role on a project to further the knowledge of Alzheimer's disease by determining key molecular mechanisms of dysregulated homeostasis by ageing and/or early-stage amyloid pathology.

This information will be used to develop novel (or repurpose existing) intervention strategies to boost homeostatic control and stabilise pathophysiological neuronal firing-rate activity.

This role is part of the UK Dementia Research Institute at Imperial, located in the Department of Brain Sciences.

Postdocs here enjoy excellent career development opportunities with:

  • Access to a range of cuttingedge technologies, i.e., 1 and 2Photon _in vivo_ microscopy, electrophysiology, automated behavioural testing, single cell/nuclei transcriptomics, noninvasive brain stimulation, IMC and computational modelling.
  • An inclusive, collegial, teamoriented working environment.
  • Strong national links through the UK DRI with attendance at its annual scientific meeting 'Connectome'.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and ECR Communities
  • The opportunity to mentor, supervise and teach students.

Duties and responsibilities:


You will:

  • Build on existing skills and experience to address major components of this project independently.
  • Present research findings as written reports, at conferences, within the College and as published manuscripts.
  • Take initiative in research planning, with clear and timely communications to the Group Leader and relevant researchers.
  • Contribute to the smooth running of the lab and facilities, acting collegiately with other scientists, clinicians, technicians and students
  • Provide guidance to staff and assist in the supervision of research students, as required
  • Maintain highly organised and accurate records of experimental work
  • Undertake appropriate scientific and professional training.

Essential requirements:

You will be a
motivated and organised researcher, excited by the science we do.


You will hold (or be near completion of)
a PhD in neuroscience (or related discipline), with practical experience of 2-Photon _in vivo_ imaging of mouse models and/or associated synaptic plasticity and neuronal micro-circuit experience.


Experience of one or more
software packages is essential: MATLAB, ImageJ, SigmaPlot, Prism, R as is experience in statistical analysis.


Further information:


This position is offered full time, fixed term initially for a period of one year with the potential for renewal, this role will be based at Hammersmith Campus.
Appointments are typically made to the first spine point of the scale. Applicants who have not yet had their PhD degree awarded will be appointed to the Research Assistant scale.

  • Closing date: _
    _2 WEEKS AFTER LISTING OR THE FOLLOWING MONDAY IF CLOSING FRI
  • SUN_

Documents:


  • JD_Research Associate Final

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