Postdoctoral Associate - University, United Kingdom - Springer Nature

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University, United Kingdom

4 weeks ago

Tom O´Connor

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Description

Postdoctoral Associate:


  • Employer
  • University of Pittsburgh School of Medicine
  • Location
  • University of Pittsburgh, Pittsburgh
  • Salary
  • Up to $64,000 annual salary + benefits
  • Closing date 8 Mar 2024
  • Discipline
Biomedicine, Life Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia- You need to sign in or create an account to a job.

Structural Biology Department, School of Medicine, University of Pittsburgh, PA, USA


Structures and Molecular Mechanisms of Biofilm Forming Functional Amyloids by Solid-state NMR & Cryo-EM

Research Infrastructure:
The Akbey Lab is funded via a startup package. We have full access to two dedicated modern solid state NMR instruments, 600 WB and 750 WB.

A variety of conventional and fast MAS probes are available, including two unique low-temperature capable 1.3mm and 3.2mm MAS NMR probes.

We have access to the NMR facility in the Structural Biology Department comprising state-of-the-art solution NMR instrumentation, including 900, 800, 700 and 2x600 MHz and several faculty with an emphasis in NMR are members of the department.

The Akbey Lab is fully equipped for recombinant protein production and characterization, with a large wet lab space and space for data analysis.

We have access to higher field ssNMR systems, ultra-fast MAS (0.7mm) and DNP via National & EU consortia.


In addition, excellent x-ray crystallography, Cryo-EM (Titan Krios, T12 & TF20), Cryo-Tomography, high-performance computation resources are available in the Department of Structural Biology.

We collaborate with faculty who are experts in these structural biology methodologies. Graduate students are part of the Molecular Biophysics and Structural Biology Program.


University of Pittsburgh and the City of Pittsburgh:University of Pittsburgh is ranked #14 in best Medical Schools in Research in USA. The University of Pittsburgh Medical School is considered a top tier medical school with a focus in research ranking in the Top 10 recipients of NIH funding. The MBSB Graduate Program consists of more than 40 PIs and collects excellent scientists, research areas and a great environment for a scientist to be and develop from University of Pittsburgh and Carnegie Mellon University.

Pittsburgh has repeatedly been ranked among the nation's most livable cities. It's truly diverse and friendly place where higher education is valued and thriving, thanks to many great universities. It has a warm, friendly culture with so much history.

A beautiful downtown, lively neighborhoods, a great art and music scene, and an influx of young professionals has made it a fantastic place to live.

Despite all it offers, Pittsburgh is still a very affordable and easy to live city (~50% less compared to New York or California).

University provides comprehensive health insurance and other resources to its coworkers.


_City of Bridges_:

Pittsburgh's 440-plus bridges (more than even Venice can boast) span three major rivers and countless streams, creeks, valleys, and ravines.

Pittsburgh airport makes it super easy to be connected to any large city in the States and World.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.


Selected recent publications related to the position: (*)**- Chang-Hyeock Byeon, Kasper Holst Hansen, Jasper Jeffrey, Maria Andreasen,
Ümit Akbey. (
2023) Initial Steps of Chaperone-Aided Fibrillation of Pseudomonas aeruginosa Biofilm Forming Functional Amyloid FapC. Biorxiv.

  • Chang-Hyeock Byeon, Pang C. Wang, In-Ja L. Byeon,
    Ümit Akbey (
    2023) Solutionstate NMR assignment and secondary structure propensity of the full length and mínimalistictruncated prefibrillar monomeric form of biofilm forming functional amyloid FapC from Pseudomonas aeruginosa. Biomolecular NMR Assignment.
-
Ümit Akbey and Maria Andreasen (
2022) Functional amyloids from bacterial biofilms - structural properties and interaction partners


Chemical Science:
13,
-
Ümit Akbey (
2022) Site-specific Protein Methyl Deuterium Quadrupolar Patterns by Proton detected 3D 2H13C1H MAS NMR Spectroscopy. JBioNMR /s

  • Nelson Ferreira, Emil Gregersen, Zachary A. Sorrentino, Hjalte Gram, Cristine Betzer, Clara Perez-Gozalbo, Marjo Beltoja, Madhu Nagaraj, Jie Wang, Jan S. Nowak, Mingdong Dong, Daniel Otzen,
    Ümit Akbey, Sissel Schmidt, Morten Meyer, Marina Romero-Ramos, Benoit Giasson, Poul H. Jensen (
    2021) Multiple system atrophyassociated oligodendroglial protein p25 alpha stimulates formation of novel alphasynuclein strain with enhanced neurodegenerative potential. Acta Neuropathologica 142, 1, 8711
  • Madhu Nagaraj; Mumdooh Ahmed; Jeppe Lyngso; Brian S. Vad; Andreas Bogglid; Anne Filipsen; Jan Skov Pederson; Daniel
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