Research Associate - South Kensington, United Kingdom - Imperial College London

Imperial College London

Verified Company

South Kensington, United Kingdom

3 weeks ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

This post is funded by the Biotechnology and Biological Sciences Research Council (BBSRC) as part of a project grant awarded to Professor Snelgrove and Dr Dean.

The post-holder will be part of Professor Snelgrove's group within the Inflammation, Development & Repair Section and Dr Dean's group within the Cardio-Respiratory Interface Section; both groups are based at Imperial College, South Kensington Campus.

The post holder will use systems well established in the groups but will have the freedom to develop novel systems to investigate our hypothesis.

Once appointed, the post holder will be involved in developing and driving the project as well as writing up work for presentation and publication.

The ability to work independently and as part of a team, excellent communication, organisational and problem-solving skills are essential.

This project provides an excellent opportunity for a driven individual to investigate an exciting research question, using a variety of cutting-edge approaches.

Duties and responsibilities:

To conduct murine models of lung injury (naphthalene and influenza) performing immunisations, assessment of histological changes, sampling of the airways and tissue processing.
To culture and manipulate primary human airway epithelial cells, with ensuing downstream assessment of phenotypic and functional changes.

- investigate phenotypic and molecular characteristics of pulmonary epithelial cells in health and disease by flow cytometry and transcriptomic analysis.

To conduct cytokine assays, histological analysis, immunofluorescence/confocal microscopy, RNA extraction and real time PCR.
To conduct and plan own scientific work with appropriate supervision.
To contribute to the design of future experiments.
To maintain highly organised and accurate record of experimental work.
To conduct data analysis, ensuring the validity and reliability of data at all times.
To contribute to the smooth running of the Group's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories.
To participate in Group research meetings and internal seminars.
To publish in high quality journals and to present data at national and international meetings.
To assist with the supervision of undergraduate and postgraduate research students and research assistants as required.
To develop contacts and research collaborations within the College and the wider community.

Essential requirements:

Research Associate: PhD degree in Biological Sciences, ideally with a high immunology content, or equivalent industrial or commercial experience.
Previous experience working in a research laboratory.
In depth knowledge of inflammation biology and immunology.
Experience of murine models of (preferably respiratory) disease, including use of complex transgenic mice.
Experience or working with primary human airway epithelial cells.
Experience of working with precision cut lung slices.
Experience with multiparameter flow cytometry and cell sorting.
Experience in immunofluorescence and confocal microscopy.
Strong publication record.

Further information:

The post is offered full time for 36 months following a successful probation period. Based at South Kensington campus until Autumn 2024, then Hammersmith campus.

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