Phd Studentship - Birmingham, United Kingdom - Aston University

Aston University

Verified Company

Birmingham, United Kingdom

3 weeks ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

PhD Studentship (3 years) Brain on "FIRE" - investigating the role of microglia in epilepsy

Department:
College of Health and Life Sciences

Contract Type:
Fixed Term

Basis:
Full Time

Closing Date: 31st
July 2023 [11.59pm GMT]

Supervisory Team:
Supervisory team: Dr Sukhvir Wright, PI (BCH and Aston); Professor Gavin Woodhall, Associate Supervisor (Aston); Dr Clare Pridans, External Supervisor (University of Edinburgh); Dr Manoj Upadhya, Associate Supervisor (Aston)

Project Reference:
HLS_Wright_Woodhall

Applications are invited for a three-year Postgraduate studentship, supported by Aston University's Institute of Health and Neuroscience and Birmingham City Hospital, to be undertaken at Aston University.

The position is available to start in October 2023.

Financial Support

Background to the Project
References: 1 Gaspard, N., et al. New-onset refractory status epilepticus: Etiology, clinical features, and outcome. Neurology 85, Dale, R. C., et al. Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. Neurology 83, Paolicelli, R. C., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 333, Schafer, D. P., et al. The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS. Glia 61, Schafer, D. P., et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, Badimon, A., et al. Negative feedback control of neuronal activity by microglia. Nature 586, Wu, W., et al. Microglial depletion aggravates the severity of acute and chronic seizures in mice. Brain Behav Immun 89, Modebadze, T., et al. A Low Mortality, High Morbidity Reduced Intensity Status Epilepticus (RISE)

Model of Epilepsy and Epileptogenesis in the Rat. PLoS One 11, e Wright SK, et al. Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis. Commun Biol. 2021 Sep 20;4(1):1106.

doi:
/s

Person Specification

Contact information

A copy of your current CV
Copies of your academic qualifications for your Bachelor degree, and Masters degree (if studied); this should include both certificates and transcripts, and must be translated in to English
A research proposal statement
A personal statement
Two academic references
Proof of your English Language proficiency

**Please include the supervisor's name, project title and project reference in your Personal Statement.