Associate Scientist - Oxford, United Kingdom - T-Cypher Bio

Description

T-Cypher Bio

Associate Scientist - Molecular Biology

T-Cypher Bio is an early-stage, innovative biotechnology company aiming to unlock an expansive target space to build a pipeline of novel, T-cell receptor (TCR)-based therapeutics.

What you will do

Key Responsibilities

• Design and execute molecular biology experiments, including DNA/RNA isolation, cloning, PCR, qPCR, gel electrophoresis, and nextgeneration sequencing
• Design and delivery of expression constructs to cells
• Engineering of cell lines for platform development
• Participate in group and project meetings, offering insights and expertise on technical elements to advance research projects
• Analyse and record experimental results and communicate findings to the team and to management
• Maintain and implement good laboratory practices, including accurate laboratory notebook systems, instrument and reagent maintenance, and personnel safety precautions

To be successful you will need

• BSc in molecular biology, biochemistry, molecular immunology, or a related discipline with relevant experience within industry or academia post BSc.
• Experience with a wide range of molecular biology techniques, such as PCR, qPCR, restriction digests, ligations, assembly methods (e.g. Gibson), mRNA production, and agarose gel electrophoresis
• Experience with DNA sequence analysis and construct design using in silico software tools (e.g. Snapgene)
• Experience with DNA extraction methods, including mini, midi and maxiprep scale
• Experience culturing E coli
• Experience with genome editing technologies such as CRISPRbased methods, baseediting, deletions, knockins and gene silencing is desirable.
• Familiarity with preparation of samples for Next Generation sequencing methods e.g. Illumina MiSeq
• Desire to own and lead research projects whilst functioning as part of a wider research team
• Ability to adapt to multiple roles in an evolving company
• Enjoy working towards challenging goals in a fastmoving environment
• Ability to follow and write protocols and SOPs
• Knowledge of health and safety regulations in a laboratory environment
• Strong organizational and communication skills (both written and verbal)

Desirable:

• Experience in cell therapy
• Experience working with peptide:HLA molecules
• T cell and Immunology knowledge
• Experience in Next generation sequencing

What we offer
Competitive salary and benefits commensurate with qualifications and experience.

Modern, well-equipped office and laboratory facilities on Oxford Science Park.

Training and development opportunities in-line with the company's goals and growth plans.

An exciting opportunity to help establish an early-stage biotech with ambitions to impact patients' lives.


How to apply
Please submit your CV and a cover letter through this posting.

Applications will be evaluated in the order that they are received.

Applications will close once the position is filled.