Research Associate in Cellular and Molecular - Manchester, United Kingdom - The University of Manchester

The University of Manchester

Verified Company

Manchester, United Kingdom

3 weeks ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

Based on the laboratory of Dr Christos Pliotas at the University of Manchester, you will work on an exciting project on dynamics and catalysis of integral membrane pyrophosphatases, aiming to determine how they pump both sodium ions and protons, to determine the mechanism (alternating or both ions pumped through a single chain at once) of this and of gate opening, and to use this as the basis for drug design.

The project combines protein production and purification, subcellular trafficking and electrophysiological measurements to determine the molecular pathways as well as the structure of this challenging system.

You will be a highly motivated individual with a strong basis in cellular and structural biology, and experience in working with integral membrane proteins.

You should have a PhD (or be close to completion) or equivalent in Molecular Biology, Biochemistry or a closely allied discipline and have previous experience in cloning, eukaryotic tissue culture, membrane protein expression and purification and/or electrophysiology.

Experience in lipid assays and structural biology would be desirable.

Our University is positive about flexible working - you can find out more here

Blended working arrangements may be considered

Enquiries about the vacancy, shortlisting and interviews:

Name:
Christos Pliotas

General enquiries:

Technical support:

**Please see the link below for the Further Particulars document which contains the person specification criteria