Phd Scholarship in Midios Microrna in Diabetic - County, United Kingdom - Springer Nature

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Tom O´Connor

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Tom O´Connor

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Description

PhD Scholarship in midios microRNA in Diabetic Osteopathy:

  • Employer
  • University of Galway (NUI Galway)
  • Location
  • Galway (County), Connacht (IE)
  • Salary
  • €18,500 per annum
  • Closing date
  • 26 Feb 2024
  • Discipline
Biomedicine
Job Type
PhD Studentship
Employment - Hours
Full time
Duration
Fixed term
Qualification
Undergraduate
Sector
Academia- You need to sign in or create an account to a job.

  • Job Details
  • Company

Job Details:


This position is funded by Science Foundation Ireland and is available from 15 March 2024 to contract end date of 28 February 2028.


Information on Project:


This project is an SFI-funded collaborative investigation including teams with expertise in cell biology, molecular biology, biomedical engineering, clinical medicine and computational biology.

The team aim to create a novel, targeted therapy for type 2 diabetes mellitus (T2DM)-induced osteopathy. T2DM involves a paradoxical osteopathy where an increase in bone mineral density results in fragility fractures. Fractures in individuals with T2DM take longer to heal, reduce mobility and elongate hospital stays.

This team will molecularly characterize the osteogenic bone marrow mesenchymal stromal cells from people living with or without T2DM, then correlate those changes with biomechanical changes in the bone.

We will then create molecular therapies to mediate the impact of T2DM on bone and assess its efficacy.


The aim of this PhD Project is to prioritize potential molecular therapeutics by correlating T2DM-induced osteopathic changes to bone composition, structure and strength with molecular changes in osteogenic progenitor cells.


Duties:


  • Laise between the cell biology, molecular biology and biomechanical engineering teams Carry out detailed characterisation of tissue samples at multiple length scales using X-Ray micro/nanoCT characterisation and biomechanical testing techniques. Culture and characterize cells isolated from human bone marrow Conduct molecular biology assays Protocol optimization, SOP writing Maintain organized records of experimental design and outputs Support the My Green Labs initiative Participate in all health and safetyrelated activities (risk assessment, record keeping, auditing) Adhesion to project timelines Report writing Manuscript writing Working closely with other REMEDI team members as part of a laboratory community Any other duties assigned commensurate to this level of post

Essential Requirements:


  • BSc or MSc qualification in the biologic sciences, preferably cellular biology, or biomedical engineering Experience with experimental characterisation of biological tissues using microscopy or other imaging techniques (preferably X-Ray CT techniques) Experience with adherent cell culture Evidence of qualitative and quantitative skills Evidence of capacity to learn technical skills, then perform the same tasks independently, reproducibly Evidence of highly detailed, accurate record keeping Excellent time management, written and oral communication skills Evidence of interpersonal skills Capacity for creative, lateral thinking, problem solving and troubleshooting

Desirable Requirements:


  • Experience with mammalian tissue culture Experience with mechanical or biomechanical testing techniques. Experience with biochemical assays, molecular biology skills Evidence of proactivity and ownership over a labbased project Prior knowledge of osteogenesis, bone composition, biomechanical testing Strong motivation to work in the field of orthopaedics
***
Salary: The PhD stipend is €18,500 per annum as determined by SFI. Annual fees will be paid to the University by the project supervisor.


Start date:
Position is available from 15 March 2024


Continuing Professional Development/Training:


Researchers at University of Galway are encouraged to avail of a range of training and development opportunities designed to support their personal career development plans.

University of Galway provides continuing professional development supports for all researchers seeking to build their own career pathways either within or beyond academia.

Researchers are encouraged to engage with our Researcher Development Centre (RDC) upon commencing employment - see HERE for further information.

Further information about the Regenerative Medicine Institute is available on our website.


Interviews are planned to be held the week of 4 March 2024
We reserve the right to re-advertise or extend the closing date for this post.

University of Galway is an equal opportunities employer.

All positions are recruited in line with Open, Transparent, Merit (OTM) and Competency based recruitment


Company:

NUI Galway is recognized as a research-led University that addresses issues of global economic and societal importance. Our research strategy focuses on developing clusters of internationally recognised expertise in selected priority areas. We have developed meaningful and strategic r
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