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Research Associate - South Kensington, United Kingdom - Imperial College London

Imperial College London

Verified Company

South Kensington, United Kingdom

1 month ago

Posted by:

Tom O´Connor

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Description

The research addresses the mechanism(s) by which cyclooxygenase-2 (COX-2) protects the cardiovascular system.

COX-2 is an enzyme located within discreet regions including the kidney, brain, gut, lungs, thymus and some areas of vascular endothelium.

In one or more of these regions COX-2 activity protects the cardiovascular system from hypertensions, atherosclerosis, and thrombosis.

We know this because common pain medications, which work by blocking COX-2, elevate an individual's personal risk of getting a heart attack or stroke by as much as 30%.

The program of work involves a multidisciplinary approach including tissue from animal models, human samples and cell based models, single and multi-analyte immune based assays and gene expression analysis using qPCR and transcriptomic approaches.

Duties and responsibilities:

You will take over a well-developed project in the lab. As part of this project, you will perform key experiments and work with our collaborators to complete ongoing experiments. You will also perform more exploratory experiments to progress novel observation

using your own initiative to design and carry out experiments to progress novel observation made within our program of research.

You will be expected to manage and maintain an up-to-date lab data archive and to optimise experiments to be able to generate robust and reproducible data.

You will work closely with members of the group and be expected to support and advise other members of the team as required.

As part of our team, you will be expected to attend meetings/conferences to present your work and receive feedback from others.

You will be responsible for complying with all aspects of governance (human tissue, health and safety etc) relating to your work and support others who your work with and/or supervise/train in governance compliance.

Essential requirements:

Research Associate: Hold a PhD in Pharmacology, or closely related, discipline, or equivalent research, industrial or commercial experience.

Research Assistant: Near completion of a PhD in Pharmacology, or closely related, discipline, or equivalent research, industrial or commercial experience.

A strong background in pharmacological approaches and cardiovascular biology

Experience working with clinical samples and contributing to associated governance and record keeping

Experience with cell culture of human vascular or inflammatory cells, single and multi analyte immunoassays, FACS analysis, imaging and other analytical approaches

Experience in molecular and cellular biology techniques including RNA extraction, qPCR, Western blotting and bioinformatic analysis of RNA sequencing data

Further information:

This position is funded by the British Heart Foundation and is Full Time and Fixed Term until the end of June 2024, based at South Kensington Campus.

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