Postdoctoral Fellow- Organoid Platform Development - Cambridge, United Kingdom - Wellcome Sanger Institute

Wellcome Sanger Institute
Wellcome Sanger Institute
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Cambridge, United Kingdom

3 weeks ago

Tom O´Connor

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Tom O´Connor

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Description

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.


About the Role:

We have an exciting opportunity for a Postdoctoral Fellow to join our Vento-Tormo Group in our Cellular Genetics Programme. The position will be for a 2 year fixed term contract with possibility of extension.


You will be responsible for:


You will be working on developing a reproductive system epithelial organoid platform model for studying interactions between the placenta and endometrium and disease.

You will be building on established organoid methods and generation pipelines to improve the existing protocols and adapt them to a high-throughput format.

The project will also involve complexification of the organoid model by adding other cellular compartments (stromal, immune, endothelial) in order to better model the in situ system.

The organoid platform will be used for genetic and drug screens. This project will involve tight collaboration with members of our and other teams, both experimental and computational.


About You:


  • Organoid culture
  • Tissue culture protocol development
  • Cellular assays
  • Single cell RNA sequencing
  • Project management skills
  • Immunology
  • Gene editing (CRISPR/Cas9) and screening

About Us:


Essential Skills:


  • PhD in cell/molecular biology, biotechnology, genetics, immunology or a similar discipline with a publication record
  • Knowledge of organoid culture
  • Proven experience with protocol development
  • Good experience with cell biology in different systems
  • Experience with single cellomics (e.g. scRNAseq)
  • Experience in carrying out both independent and collaborative research
  • Highly developed communication skills to engage effectively with a wideranging audience, both orally and in writing, using a range of media
  • Ability to plan and prioritise own work in order to meet deadlines, including using initiative to plan research programmes
  • Working collaboratively with others and building working relationships with stakeholders at all levels
  • Demonstrates inclusivity and respect for all
  • Commitment to personal development and updating of knowledge and skills

Desirable:

  • Experience with iPSC differentiation protocols
  • Experience with immune cell culture
  • Experience with cellular assays
  • Experience with gene editing technology (CRISPR/Cas9) and screening processes

Other Information:


Salary per annum (dependent upon skills and experience) £35,707-£44,712


Application Process:


Closing Date: 7th July 2023

Working at Wellcome Sanger:

Our flexible-hybrid working environment is designed to support a healthy work-life balance.

This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.


We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world.

We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness.

The networks are also a place for allies to provide support to others.


We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work.

That's why we're committed to creating a truly inclusive culture at Sanger Institute.

We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.


Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme.

The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

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