Research Assistant - Newcastle upon Tyne, United Kingdom - Newcastle University

Newcastle University
Newcastle University
Verified Company
Newcastle upon Tyne, United Kingdom

2 weeks ago

Tom O´Connor

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Tom O´Connor

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Description

Salary:


Research Assistant:
£29,619 to £31,411 per annum


Research Associate:
£32,248 per annum

Newcastle University is a great place to work, with excellent benefits.

We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.


Closing Date: 01 February 2023

The Role


We are looking for an experienced Research Assistant/Associate to work on the following project: "Towards Chemotherapy-Free Treatment of Paediatric Post-Transplant Lymphoproliferative Disorders".

You will be responsible for curating diagnostic tissue samples taken from children developing post-transplant lymphoproliferative disorder.

Those samples will be processed to extract DNA/RNA which will be sent for genetic and transcriptomic analysis using NGS panel sequencing, DNA copy number array and NanoString approaches.


You will be responsible for the downstream analysis of the data returned, looking to identify and validate both mutational and copy number features.

You will also analyse the NanoString transcriptional data to define the tumour immune microenvironment, to be compared with clinical data to identify factors associated with outcome.


The post will also include providing wider support to junior laboratory group members, including the supervision of undergraduate and postgraduate students.

You should have a detailed understanding of childhood lymphoma biology and genomics.

You should have first-hand experience of the tasks involved in this project, most notably the extraction of nucleotides from tumour specimens and subsequent library preparation.

You should also be able to demonstrate skills and experience in the analysis of next generation sequencing data, copy number array data and Nanostring transcriptomic data and be able to demonstrate an understanding of the analysis of clinical outcome data in relation to identified genetic features.


You will have excellent basic wet laboratory skills including accurate pipetting, careful handling and storage of irreplaceable tissue samples and derivatives and high quality preparation of DNA/RNA for NGS, copy number array and NanoString experiments and excellent skills in the analysis of NGS and Nanostring data with experience of analytical programmes and environments such as IGV, Nexus, nSolver and R studio.

This is a full time post, fixed term until 31 October 2023

Key Accountabilities
Although working under the general guidance of an academic Principal Investigator with advice and support where required, the appointee should:

  • Determine appropriate methodologies for the research
  • Design and perform laboratory experiments
  • Interpret research data in the context of existing knowledge
  • Contribute with new ideas, providing substantial 'added value'
  • Contribute to the writing up of their research and its dissemination, either through seminar and conference presentations or through publications
  • Participate in the supervision of Undergraduate and Masters research projects and providing support to Postgraduate research students and other laboratory members
  • Start to develop an awareness of University structures, policies and procedures and relevant issues in the higher education and research environment
  • Potentially contribute to events encouraging public engagement in science and supporting fundraising activities
  • Work well with support staff, students, researchers and other academic members of the Institute
The Person (Essential)

Knowledge, Skills and Experience

  • Detailed knowledge of the molecular features and biology of childhood lymphomas / lymphoproliferative disorders
  • Experience of working with frozen and formalinfixed paraffinembedded human tissue
  • Experience in nucleotide extraction and library preparation
  • Experience in processing and analysis of next generation sequencing data to identify mutations
  • Experience in processing and analysis of copy number data from different sources
  • Experience in processing and analysis of NanoString data
  • Experience of analysis of tumour immune microenvironment
Attributes and Behaviour

  • Advanced technical and interpretative skills directly related to the research project
  • High level of analytical and problem solving capability
  • Ability to communicate complex information with clarity and to encourage the commitment of others
  • Good time management and ability to prioritise to meet deadlines
  • Honesty, probity and a commitment to good scientific practice

Qualifications:


  • A relevant PhD or equivalent professional / higher education qualification (for Research Associate) or experience in the specific research area (for Research Assistant) required
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