Research Associate - Cambridge, United Kingdom - T Therapeutics Ltd

Description

Research Associate / Scientist - Technology & Protein Science

About the Opportunity
We are seeking a highly motivated research associate/scientist to join the protein engineering, expression, purification and characterisation team.

This is a fantastic opportunity to join the team at an early stage and contribute towards engineering and developing novel soluble TCR-based therapeutics.

As an early team member, you would have the opportunity to be involved in supporting the development of our novel TCR formats.

This role would suite individual who thrive in working in a dynamic environment and is flexible to learn and adapt as the team expands.

In this role you will be responsible for:

• DNA cloning and preparing DNA constructs for transfections
• Expressing novel TCR formats in HEK293 and CHO cells in small, medium and large scale
• Perform protein purification and ensure proteins are of highquality using protein analytical and assay techniques (SDS-PAGE, HPLC-SEC, ELISA)
• Maintain and establish cell lines required for protein production
• Provide highquality protein material to the downstream protein characterisation team
• Support protein team in functional and biophysical characterisation
• Analyse and present work/data in group meetings and produce accurate scientific reports and SOPs
• Maintain uptodate and accurate laboratory record of all experimental activities

About you

• Handson experience in protein production in mammalian cells such as proteinbased biologics (e.g. antibodies or other biologics) and protein purification
• Experience with protein expression in E. coli and troubleshooting difficult expression would be highly desirable
• Practical knowledge of the AKTA purification platform and using conventional chromatography resins e.g. ion exchange
• Good working knowledge of a range of methodologies to characterise proteins
• Mammalian cell culture aseptically culturing and maintaining cell lines, transfections for protein production
• Knowledge and/or experience in antibody or soluble TCR development would be highly desirable
• The ability to plan and execute to clear timelines, working under pressure and being able to prioritise projects and daily workload
• Strong organisational skills with a proven ability to analyse complicated data in a logical and understandable format
• The ability to work independently and actively collaborate with crossfunctional teams and influence work outcomes is an advantage
• Excellent communication (written and verbal) and interpersonal skills

Salary:
£30,000.00-£45,000.00 per year


Benefits:

• Company pension
• Free parking

Schedule:

• Monday to Friday

Supplemental pay types:

• Bonus scheme

Ability to commute/relocate:

• Cambridge, CB21 6AD: reliably commute or plan to relocate before starting work (required)

Education:

• Bachelor's (required)

Experience:

- worked in the research lab before (required)


Work Location:
In person


Reference ID:
Technology Protein Science (HA)