Plrs- Pharmacology Expert - London, United Kingdom - Francis Crick Institute

Francis Crick Institute
Francis Crick Institute
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London, United Kingdom

1 week ago

Tom O´Connor

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Tom O´Connor

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Description

PLRS- Pharmacology Expert:


  • Employer
  • Francis Crick Institute
  • Location
  • London (Central), London (Greater) (GB)
  • Salary
  • From £58,000 with benefits, depending on skills and experience
  • Closing date 26 May 2024
  • Discipline
Chemistry
Job Type
Researcher
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
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Job Details:


Pharmacology Expert

Reports to:
Head of Chemical Biology STP

This is a
full-time, permanent position on Crick terms and conditions of employment


Overview


The position is within the Chemical Biology Science and Technology Platform (STP), a newly formed and expanding interdisciplinary group, at the Francis Crick Institute.

Is it also closely aligned with the High Throughput Screening STP and will involve leading the development of compound profiling approaches for tractability evaluation and tool, probe and drug discovery projects, requiring input from the two groups.


The HTS STP provides researchers with access to the specialised knowledge and infrastructure to undertake large-scale screening as part of their discovery research.

This usually takes the form of arrayed screens using siRNA, CRISPR and chemogenomic reagents primarily in cell-based assays with high content imaging readouts.

However, with the advent of the Chemical Biology STP, there is the opportunity to expand the horizons of what is possible for researchers to undertake at the Crick.


Role Summary

Key responsibilities will include;

  • Work closely with STP leadership (including Chemical Biology, HTS, Structural Biology, Proteomics, NMR) to establish stateoftheart crossSTP screening approaches for hit identification, validation and optimisation against novel targets; establish suitable assay technologies that enable the selection of potential probes and therapeutics.
  • Where appropriate, build relationships with CROs to expand access to novel assay capabilities.
  • Contribute to interdisciplinary drug discovery teams as pharmacology/assay lead, taking accountability for the development of complex biological assays and the elucidation of mechanism of action.
  • Where appropriate, take on overall project leadership of drug discovery activities in these teams.
  • Demonstrate scientific leadership through acting as assay area expert; stay abreast of the latest literature and developments in the field; propose and drive technology projects that optimise/modernise the current drug discovery process.
  • Raise the profile of the STP and Crick translational science by publishing and presenting internally and externally.
  • Train, mentor and, where appropriate, line manage less experienced scientists working in assay development and compound screening.
  • Support the recruitment of assay scientists into interdisciplinary teams for early drug discovery projects.
  • Make broad contributions to translational science at the Crick, working closely with the translation team to provide pharmacology and drug discovery expertise on nascent translational projects.

Key experience and competencies
The post holder should embody and demonstrate our core Crick values: Bold, Open, and Collegial, in addition to the following:


_Essential:
_

  • Deep knowledge of pharmacological principles and the ability to interpret quantitative data sets from compound profiling experiments.
  • A strong track record in the design and development of in vitro biochemical assays in a drug discovery context, utilising multiple technologies.
  • Knowledge and/or demonstrated experience in the design and development of cellbased assays, across multiple cell types and utilising multiple technologies.
  • Experience of using laboratory automation for compound screening in an industrial setting and software solutions for complex data analysis.
  • Proven ability to demonstrate leadership capability and skills in own area of scientific expertise.
  • Excellent communication skills within a research environment, building highly effective working relationships with team and collaborators.
  • Learning agility, initiative and drive; demonstrated ability to quickly develop new skills and gain an understanding of unfamiliar scientific areas.

_Desirable:
_

  • Broad knowledge of strategies to validate assay relevance to disease.
  • In depth knowledge of at least one therapeutic area and a proven track record of leading and influencing scientific research.
  • Practical experience in the characterisation of isolated targets, which could include compound/inhibitor mechanism studies and catalytic mechanism determination.
  • Experience with multiparametric cellular detection systems such as highcontent imaging, flow cytometry, highthroughput sandwich immunoassays.
  • Experience of industryacademia partnering and/or IP.
  • An awareness of Medicinal Chemistry principles for the selection, design and optimisation of small molecule chemical probes for u
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