Research Associate - Cambridge, United Kingdom - University of Cambridge
Description
Fixed-term: The funds for this post are available until 28 February 2026 in the first instance.
The aim of this interdisciplinary project is to develop an approach for detecting biomarkers that allow early diagnosis of Parkinson's disease, provide a means to track disease progression, and support the development of future therapeutics.
A particularly attractive route to achieve this objective is to directly measure the seeding activity of misfolded and aggregated forms of the central protein driving Parkinson's disease (PD), alpha-synuclein.
Yet, the ability to measure and quantify the seeding activity of pathological aggregates in clinical samples has remained elusive.Here, we propose to address this challenge by developing a quantitative and practical seeding assay in digital format which allows better quantification.
Success with this project will open a platform and path towards quantitative PD biomarker detection.
Applicants will be expected to work collaboratively in an interdisciplinary environment, interact and communicate effectively with a team of scientists with a wide range of expertise in biophysics and physical chemistry.
Those who have submitted but not yet received their PhD will be appointed at the Research Assistant level, which will be amended to Research Associate once the award of the PhD has been confirmed.
The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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