Research Experience and Publications, Talks and Work

Recent Research, Presentations and Publications

Research Proposal        Principle Investigator (PI) in Observational study of treatment history, quality of life, treatment satisfaction, and disease symptom severity in adult patients with moderate to severe plaque psoriasis treated with bimekizumab in routine clinical practice (ELEVATE) sponsored by UCB Bioscience GmbH (IRAS ID 315744) is to be commenced in 2024, planned for a study duration of 3 years and 25 days in the UK. Participants are prescribed Bimzelx® (bimekizumab) by their treating physician according to standard medical practice and are being asked to allow collection of their data. This data collection survey is a non-interventional study (NIS) which is initiated, managed, and financed by UCB Biopharma SRL who is the Sponsor of this NIS. The purpose of this NIS is to collect medical information about the treatment after having taken Bimzelx® so that a record of whether Bimzelx® causes any side-effects, and see whether Bimzelx® does or does not have any effect on the participant’s health-related quality of life. In addition, information on the degree of treatment satisfaction with Bimzelx® will be collected.

July 2024          Speaker at Eli Lily® Sponsored Symposium in 104th BAD Annual Conference: The Biologic Conundrum/Management of Plaque Psoriasis and Arthropathy/Dermatology Workforce Challenge

05/12/2019 - Present     Principal Investigator (PI) for an Observational Study entitled VALUE. This is an observational study of patients with moderate to severe plaque psoriasis in the United Kingdom, and approximately 20 other countries worldwide. The study population will consist of adult subjects (aged ≥18 years) with moderate to severe plaque psoriasis. A total study target sample of 180+ patients have recruited from the UK over approximately 15 to 20 NHS hospitals. The study research data has been obtained from the medical records and entered into an electronic case report form (eCRF) by the physician or members of research teams. One eCRF was to be completed for each patient per visit (every 3-4 months as per clinical practice) for up to 3 years. The study is eligible for NIHR portfolio inclusion (REC reference: 19/LO/1401), duration of Study in the UK was planned to go on for 4 years and 6 months. Study was sponsored by Abbvie Ltd.

Apr 2024           Real World Data Updates speaker on the treatment of Chronic Plaque Psoriasis with Biologic Therapy in Farnborough, a local (Frimley Health FPH/WPH Dermatology) educational and promotional meeting sponsored by Eli Lily. 

Mar 2024:         Dermatology x Rheumatology Study Day sponsored by UCB. The Use of Bimekizumab an Il-17A/F inhibitor in the Management of Chronic Plaque Psoriasis: Case Studies presented by Dr CM Lee Consultant Dermatologist, coupled with Consultant Rheumatologist: Dr P Sharma – the dual perspectives in managing PsA and PsO. 

Nov 2023:         Frimley Skin Cancer Symposium. Speaker for ‘Actinic Keratosis and Management Options’, 10 November, Surrey (6cpd). 

Oct 2023:          Speaking at Sponsored Symposium: Discussions in Dermatology. Real world experience (case studies) and Insights into Baricitinib for Atopic Dermatitis, 19-20 October, Birmingham (7cpd)

Sept 2023:        Chun-Man Lee, "A Review on the Antimutagenic and Anticancer Effects of Cysteamine," Advances in Pharmacological and Pharmaceutical Sciences, vol. 2023, Article ID 2419444, 14 pages, 2023. 

                        Patient Survey: Treatment satisfaction of adult patients with moder-to-severe AD treated with baricitinib in the UK CM Lee, D Al-Ismail, B Gittens, R McKenzie, C Mert, HJA Hunter displayed at the 32nd British Dermatology Nursing Group Annual Conference, Harrogate.

May 2023:         FPH Dermatology Journal Club monthly meeting. Review of Literature for Risk Stratification and Surgical Excision Margin for Basal Cell Carcinoma. Chaired and Presented.

Feb 2023:         SouthWest Thames (Regional) Virtual Dermatology Meeting, as organiser, chair, and presenter of audit project and case reports.

Sept 2022:        Dermatology Live Learning by La Roche Posay, in which I presented Skin Barrier and Atopic Dermatitis.

At The Dermatology Partnership Evening I presented Clinical data on skincare and its clinical implications and Q&A, sponsored by The Dermatology Partnership and Eucerin

July 2022:         Atopic Dermatitis and Allergy DPHC Primary Care Clinical CPD Programme – Dermatology (Webinar). In this CPD accredited session, I described pathophysiology of AD, its link with allergies and advised a treatment strategy as well as counselling for parents seeking allergy testing. 

Case Report “An unusual suspect” S.Sherif, CM Lee, R Stitson. Well syndrome in a 32 year old diagnosed based on clinical features, confirmed on histology. Case was displayed as e-Poster at 102nd BAD Annual Meeting in Glasgow.

Nov 2021:         Skin Barrier and Atopic Dermatitis speaking at BMJMasterClass: Dermatology online conference

Oct 2021:          A Review of Products and Scientific Data in Efficacy and Safety of Ixekizumab Taltz® in the management of Plaque Psoriasis and Baricitinib Olumiant® in Atopic Dermatitis: Scratching the surface of Plaque PsO and AD, presented by Dr CM Lee FPH, Principle Investigator in VALUE study.

                        Skin Barrier, Atopic Eczema and Allergy by Dr CM Lee, participating as a speaker at UK National DermSoc Day, British Association of Dermatologists, London

Sept 2021:        FPH Dermatology Journal Club: A recap and summary of AJCC 8th ed. and Validation of a sentinel node positivity nomogram for melanoma MA El Sharouni et al.

Jul 2021:           Introducing Olumiant™ sponsored by Eli Lily, presented by Dr Chun-Man Lee. Baricitinib a high affinity oral JAK1/2 inhibitor licensed for Atopic Dermatitis; its safety and efficacy in clinical trials and clinical implications were discussed at this meeting.

Apr 2021:          La Roche Posay Sponsored Dermatology Live Learning: Skin Barrier and Atopic Dermatitis by Dr Chun-Man Lee. Talk objectives: 1. What is atopic dermatitis (eczema)? to understand terminology in the diagnosis and management of atopic eczema and inflammatory skin diseases 2. Skin barrier and immunology: pathophysiology of atopic dermatitis and its link with allergies 3. Therapeutics for impair skin barrier and demystifying the science of moisturising (CPD accredited)

                        Psoriasis, a real-world experience with case studies. Abbvie Sponsored Virtual Meeting: Safety, Efficacy and Case Studies on SKYRIZI, by Dr Chun-Man Lee (CPD accredited)

March 2021:      Abbvie Sponsored DERMATOLOGY INSIGHTS from UK Specialists: Hot Topics and Real-World Case Studies. Psychodermatology: Review the psychological burden of psoriasis on patients and HCPs; Evaluation outcomes of SKYRIZI (risankizumab) therapy in real-life psoriasis patient cases, presented by Dr Chun-Man Lee: A case study – reviewing outcomes in biologic experienced patients CPD accredited

Dec 2020:         Lee, Chun-Man. Correspondence "A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women: the devil is in the detail." Int. j. dermatol (2020)

Nov 2020:         Clear Horizons Local Meeting sponsored by Abbvie Pharmaceuticals. I presented in a virtual meeting to cover topics including targeting Il-23 p19 in Psoriasis and the Review of Clinical Data for SKYRIZI in the treatment of Psoriasis.

Feb 2020:         CM Lee, Understanding Moisturisers. “Clinical Practice” on Moisturisers, a peer-reviewed article published in magazine, Aesthetics Journal available online @aestheticsjournaluk. Volume 7/Issue 3, Feb 2020. pages 55-59.

Feb 2020:         SouthWest Thames (Regional) Dermatology Meeting, as organiser and presenter of the meeting hosted in Frimley Park Hospital (4 CPD), in which I presented and discussed two audits and three cases: Sporotrichosis, a rare case of Annual Elastolytic Giant Cell Granuloma, and a scleroderma mimicry: Sclerodema

Dermatology teaching for Paediatricians: Common and Serious Drug Reactions in Children (1hour), PGEC Frimley Park Hospital.

Jan 2020:         FPH Dermatology Journal Club: Atopic Eczema: Facts versus Myths. A discussion of current management and guidelines, in addition to pathophysiology and the link between atopic eczema and allergies (based on current literature).

Oct 2019:          Case Report “Sporotrichoid lymphangitis: what’s in a name?” e-poster displayed in 28th EADV Scientific Congress, Madrid, Spain

Dermatology teaching for Paediatricians: Atopic Dermatitis: Prevention, Diagnosis and Treatment Options (1hour), PGEC Frimley Park Hospital.

Sept 2019:        Case Report “A case of Bicalutimide-induced photosensitivity reaction” e-poster displayed in 49th Annual Meeting of European Society for Dermatological Research (ESDR), Bordeaux, France

August 2019:     Lee, C.M., R.E.B. Watson, and C.E. Kleyn. "The Impact of Perceived Stress on Skin Ageing." Journal of the European Academy of Dermatology and Venereology (2019). 

Mar 2019:         Southern Dermatology Masterclass, Guildford. I gave an hour long lecture to upskill the knowledge of circa 45 Healthcare professionals including GPwSI and Specialist nurse from across Hampshire and regions. Speaking on “Psoriasis and Management” I summarised the pathophysiology of psoriasis based on the latest scientific evidence, and the investigation and management of Psoriasis of skin.

Medical GroundRound, FPH. “Nodular Lymphangitis: Sporotrichois and PVL-Staph Infections”. A memorable case of a perfectly healthy builder having an indolent onset of inflammatory lesions and cutaneous abscesses with sporotrichoid spread. Histology gave the initial confirmation of suspicion of sporotrichosis, as well as incidental finding of PVL-staph, but final confirmation would have been via microbiological studies. The discussion took place, with consultant microbiologist Dr Garner giving his views as well as sharing knowledge on the subject matter.

FPH Dermatology Journal Club, FPH. Presented “Cheng, Harriet S., and Marius Rademaker. "Monitoring methotrexate-induced liver fibrosis in patients with psoriasis: Utility of transient elastography." Psoriasis: Targets and Therapy 8 (2018): 21.” in Departmental Meeting, setting direction for the team in clinical practice.

Jan 2019:          FPH Dermatology journal Club, FPH. Chaired and presented “Robinson et al. “Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo” Journal of Investigative Dermatology 2010.

Nov 2018:         Medical GrandRound, FPH. “Sweet’s Syndrome associated with SLE”. A memorable case of 13 year old acquiring autoimmune hepatitis, symptoms being subtle but skin presentation alerted GP and triggered a referral. A link was established between Sweet’s sx and SLE via literature research. A GrandRound presentation in which I presented my clinical reasoning and differential diagnoses.

Oct 2018:          FPH Dermatology Journal Club, FPH. Chaired and presented “Pigment-lightening effect of N, N’dilinoleylcystamine on human melanoma cells” BJD (2004). Chaired and Presented, discussed and appraised paper. Agenda and Minutes produced.

July-Nov 2018:   International Video Conferencing, organised by ScientisPharma ltd. I was an invited speaker known for my knowledge in the field “Cysteamine: a novel treatment for epidermal Melasma” speaking on 3 Webinars to dermatologists, and plastics and reconstructive surgeons on the topic of dyspigmentation disorders and currently available topical treatments. 

May 2018:         Regional GP Dermatology Training Day, FPH. “Atopic Eczema and Psoriasis: Pathophysiology, Clinical Investigations, and Therapeutics” in two 20 minute lectures.

Mar 2018:         Medical GrandRound, FPH. “Atopic Dermatitis and red and scaly rashes”. A talk centred on the immunological background of AD, diagnosis & management plan and differentiating features from other inflammatory dermatological conditions.

Regional Teaching Day for Core Medical Trainees (CMT), FPH. “Dermatology: Dermatological Emergencies and General Dermatology”, to which I contributed two talks (2 hours) to cover Derm Emergencies and common but less serious inflammatory dermatological conditions, at a level practical for trainees in Core Medical Training. Style and content of presentation were well-received (with feedbacks).

Feb 2018:         SouthWest Thames (Regional) Dermatology Meeting, as chief organiser and chairperson of the meeting hosted in Frimley Park Hospital (4 CPD), in which I presented and discussed two audits and two cases:

1. Presented findings of ‘Selecting “high-risk” SCC cases to be kept under close surveillance’, with endorsement of a 5 year follow-up plan
2. Presented data of clinical audit of quality of patch testing in contact allergy and recommended some key changes
3. Case presentation of Chronic Psoriasis with recalcitrant facial cellulitis and lymphoedema, attributed to ‘paradoxical’ TNF-alpha induced Psoriasiform Dermatitis
4. Case Presentation of Bullous Lupus with the proposal of treating with a combination of dapson and hydroxychloroquine

Dec 2017:         Lee CM. Laser-Assisted Hair Removal for Facial Hirsutism in Women: A Review of Evidence. Journal of Cosmetic and Laser Therapy. 

Sept 2017:        Case Report “Necrobiotic Xanthogranuloma with IgG Kappa paraprotein, treated successfully with Lenolidomide, a potent derivative of Thalidomide” e-poster displayed in 26th EADV Scientific Congress, Geneva, Switzerland.

Nov 2016:         Medical GrandRound, Frimley Park Hospital. “Practical Psoriasis: a discussion of what is new and currently available”.

“SouthWest Thames Regional Dermatology and Allergy Teaching for General Practitioners” (2 days, 6 cpd) as a co-founder, organiser, as well as chairperson of the meetings, hosted in Royal Surrey County Hospital. Sponsorship received from Galderma (UK) Ltd. I presented clinical updates regarding pathophysiology and treatment options for psoriasis.

August 2016:     I Presented in “Dermatology for MRCP Part 1” at a privately run exam revision course “PassMRCP Weekend High Yield Lectures”, St George’s Hospital, London. Excellent feedbacks received.

August 2016:   Lee, CM. “Fifty Years of Research and Development in Cosmeceuticals: A Contemporary Review.” Review Article published in Journal of Cosmetic Dermatology

July 2016:         Local Educational Meeting, PGEC, Frimley Park Hospital. Dermatology teaching for Junior Doctors (all medical specialities): Hair Loss

Mar 2016:         Local Educational Meeting, PGEC, Frimley Park Hospital. Dermatology teaching for Junior Doctors (all medical specialities): Red and Scaly Rashes

Jan 2015:         Lee CM, Leadbetter HK, Fishman JM.  "A Case of Oropharyngeal Bullous Pemphigoid Presenting with Haemoptysis," Case Reports in Otolaryngology, vol. 2015, Article ID 631098, 4 pages, 2015.