Research Associate X 3 - Cambridge, United Kingdom - University of Cambridge

University of Cambridge
University of Cambridge
Verified Company
Cambridge, United Kingdom

2 weeks ago

Tom O´Connor

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Tom O´Connor

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Description

Applications are invited for three PDRA positions to be part of an interdisciplinary team spanning the Departments of Pharmacology, Biochemistry and Chemistry, University of Cambridge.

The aim is to create Modular Activator and Silencer Therapeutics (MAST) by developing novel platforms of antibodies, E3 ligase-mediated degraders, and proteases, to advance drug discovery.

We are looking for motivated scientists with a strong team spirit to work on achieving the goals of MAST, with mentorship support from the labs of Laura Itzhaki (degraders; PMID , Paul Miller (ion channel antibodies; PMID , Florian Holfelder (proteases; PMID , Mark Howarth (antibodies; PMID , Catherine Wilson (degraders; PMID , and Pietro Sormanni (antibody design; PMID See the document below for more info on groups.


This project provides opportunities for creative protein engineering, including database mining (to build structural antibody/ligase/protease libraries), machine learning (AI) approaches to antibody design and interpretation of directed evolution trajectories of proteases, phage display, structural biology (X-ray/cryo-EM) of ion channels and ligases to understand antibody modulation, cell biology and advanced degrader/protease kinetic analysis, and directed protein evolution.


The applicants will have completed a PhD (or soon to be awarded one) and will have appropriate experience in at least one or more of the approaches described above and/or foundational skills in molecular biology/cloning, biophysics, protein expression and purification, biophysics & synthetic biology.


The funds for this post are available from 14th May 2024 with flexibility in the precise start date and continue for 24 months.

Online or in-person interviews are anticipated to take place in April.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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