Director of Pharmacometrics - Oxford, United Kingdom - Exscientia

Description

About Us

Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.

Our pipeline demonstrates our ability to rapidly translate scientific concepts into precision-designed therapeutic candidates, with more than 15 projects underway. By designing better drugs, faster, we believe the best ideas of science can rapidly become the best medicines for patients.

The Role

As Director of Pharmacometrics you will develop and implement model-informed drug development (MIDD) across the development portfolio to optimise study designs and to inform drug development strategies and decision-making. This includes development and application of population PK, PK/PD, exposure-response and other models (such as Model Based Meta Analysis) and working in a collaborative, multidisciplinary manner to improve project team decision-making. You will contribute to activities including integrated efficacy and safety evaluation, dose prediction, biomarker selection, clinical trial design, and regulatory documents and interactions.

Please note this is a hybrid role and occasional travel is required to our offices in Oxford, UK (approximately once per quarter), with flexibility to work from home in the UK the remaining time. We are a flexible working organisation and we're willing to consider other options which would provide similar contact time with the team.

You will have the opportunity to:

• Develop and execute innovative modelling & simulation (M&S) strategic plans for projects in various disease areas and different stages of product development.
• Develop (population) pharmacokinetic and (population) pharmacodynamic models and apply empirical and/or mechanistically-based drug disease models.
• Conduct simulations to inform drug development decisions such as starting dose, efficacious dosage regimen selection and other aspects of trial design.
• Communicate the outcome of M&S analysis to project teams to support decision making.
• Contribute to responses to health authority requests and interactions.
• Collaborate with partners in project team(s) regarding all aspects of M&S to appropriate integration of M&S strategy and results into internal and external project documents (e.g. Clinical Development Plan, Investigator Brochure, NDA documents).

Requirements

• PhD, PharmD, Msc or MD (in natural sciences, mathematics, physical sciences or engineering)
• 10+ years experience in clinical drug development and 7+ years planning and conducting M&S projects for clinical study data.
• Strategic mindset and clear vision of how and when M&S can contribute value in drug development.
• Significant experience with M&S software (e.g. NONMEM, Monolix, Phoenix, MATLAB, Gastroplus, Simcyp, SAS, R, etc.).
• Keen interest in technological advances (e.g. Bayesian modelling).
• Ability to influence and lead without authority in a matrix organisation and strong written and oral communication.

Benefits

• Join our inclusive, collaborative and intellectually stimulating organisation with strong company values.
• As a learning organisation, we provide access to learning and development opportunities and will place you at the forefront of your career growth at Exscientia.
• We employ brilliant people so we pay highly competitive salaries. Additionally, all our employees are eligible for a company-wide annual bonus and receive both a new joiner and annual share award.
• Enjoy our generous holiday allowance and flexible working approach to find a healthy work-life balance that works for you.
• Create amazing memories or progress your personal and professional development with our four-week paid sabbatical after four years of service.
• We're leading the way in progressive leave, offering enhanced policies such as generous parental leave, surrogacy, menopause, and family emergency leave so you feel supported no matter the life event.
• Additionally, we support childcare costs for children aged 0-5 through our affordable childcare scheme.
• Take advantage of two generous salary exchange schemes to claim discounts on a brand new electric vehicle and cycling equipment worth up to £3,500.
• As a healthcare company, we understand the importance of health and wellbeing so we provide comprehensive private health insurance, dental and vision benefits for you and your family.
• We also provide plenty of access to mental health support including therapy and counselling sessions plus an employee assistance program for help with lifestyle issues such as bereavement, family problems or money management.
• To help safeguard the future for you and your loved ones, we also offer pension and life cover.
• Help yourself to free drinks and snacks in our fully stocked kitchens. Join your colleagues in one of our many breakout areas and get to know the people you are working with. Some of the best ideas start with a coffee break
• Feel inspired in our high spec labs where you will use state-of-the-art equipment and instrumentation that enable you to do your best work.
• We'll even support your home office environment with an allowance for furniture and equipment to make your space as comfortable and productive as possible.
• Learn more about why our team enjoy working at Exscientia here