Research Fellow - Birmingham, United Kingdom - University of Birmingham

University of Birmingham
University of Birmingham
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Birmingham, United Kingdom

3 weeks ago

Tom O´Connor

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Tom O´Connor

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Description

Position Details
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences

Location:
University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £33,348 to £43,155 with potential progression once in post to £45,737

Grade 7

Full Time, Fixed Term contract up to November 2027

Closing date: 31st August 2023


Background
This post is funded for five years by the NIHR Birmingham Biomedical Research Centre (BRC).

The Centre, led by University of Birmingham and University Hospitals Birmingham NHS Foundation Trust, is a joint initiative along with six other organisations to support research into inflammatory diseases.


This post is based within the Cancer theme of the BRC, led by Professor Joanna Parish who will be the direct line manager for this post.

The project is specifically designed to understand how oncogenic human papillomavirus (HPV) drives cancer development and how we can target these infections to design targeted novel therapies.

The Parish lab uses state-of-the-art primary cell based models of HPV infection to define molecular signatures for diagnosis, prediction and therapy.

We will interrogate HPV-induced transcriptional reprogramming of primary human cells through the analysis of virus-induced structural and functional chromatin changes.

Future work will then aim to identify and develop novel targeted treatments for HPV-driven disease.


Role Summary

  • Work within the BRC Cancer theme to work on virallydriven cancers and novel therapeutic interventions
  • Operate within area of specialism
  • Analyse and interpret research findings and results
  • Contribute to generating funding
  • Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar

Main Duties
The responsibilities may include some but not all of the responsibilities outlined below.

  • Design and conduct laboratorybased experiments under the guidance of the research supervisor to test the project hypotheses and complete project aims.
  • Develop research objectives and proposals for own or joint research, with assistance of a mentor if required.
  • Contribute to writing bids for research funding.
  • Analyse and interpret data.
  • Disseminate research findings for publication, research seminars etc.
  • Supervise students on research related work and provide guidance to PhD students where appropriate to the discipline.
  • Design and develop new models, techniques and methods.
  • Be aware of the risks in the work environment and contribute to COSSH and other regulatory assessments when appropriate.
  • Undertake management/administration arising from research.
  • Communicate progress to supervisor and BRC team as appropriate. May require communication to patient representatives.
  • Contribute to Departmental/School researchrelated activities and researchrelated administration.
  • Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the College and the University, often under supervision of a project leader.
  • Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews.
  • Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters.
  • Provide guidance, as required, to support staff and any students who may be assisting with the research.
  • Deal with problems that may affect the achievement of research objectives and deadlines.
  • Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.

Person Specification

  • First degree in area of specialism and a PhD (or near to completion) relevant to research area or equivalent qualifications.
  • Experience of primary cell culture methods.
  • Experience in methods of chromatin analysis including ChIP/ChIP-Seq, RNA-Seq and/or ATAC-Seq.
  • Experience in PCR techniques including RTqPCR and endpoint PCR.
  • Experience of cell culture and analysis of protein expression technology such as SDS-PAGE.
  • High level analytical capability.
  • Ability to communicate complex information clearly.
  • Fluency in relevant models, techniques or methods and ability to contribute to developing new ones.
  • Ability to assess resource requirements and use resources effectively.
  • Understanding of and ability to contribute to broader management/administration processes.
  • Contribute to the planning and organising of the research programme and/or specific research project.
  • Coordinate own work with others to avoid conflict or duplication of effort. Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected. characteristics are treated equally and fairly.
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