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University of Cambridge Cambridge, United Kingdom Full time, Fixed-Term/ContractA fully funded PhD studentship is available under the supervision of Dr Shelly Singh-Gryzbon, with a start date of 1 October 2024. Funding will cover the student's stipend and tuition fees at the UK rate. Non-UK applicants will be considered only if they can fund the overseas fee ...
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Senior/Chief Cardiac Physiologist
1 week ago
West Suffolk NHS Foundation Trust Bury St Edmunds, Suffolk, United KingdomAre you looking for a new and exciting challenge? Are you committed to delivering the best and safest care to patients? Would you like to work in a dedicated Cardiac Centre which is continually expanding its services? This is a great opportunity to develop your clinical skills, p ...
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Senior/Chief Cardiac Physiologist
2 weeks ago
West Suffolk NHS Foundation Trust Bury St Edmunds, Suffolk, United KingdomAre you looking for a new and exciting challenge? Are you committed to delivering the best and safest care to patients? Would you like to work in a dedicated Cardiac Centre which is continually expanding its services? This is a great opportunity to develop your clinical skills, p ...
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Senior/Chief Cardiac Physiologist
1 week ago
West Suffolk NHS Foundation Trust Bury St Edmunds, United Kingdom PermanentJob summary · Are you looking for a new and exciting challenge? Are you committed to delivering the best and safest care to patients? Would you like to work in a dedicated Cardiac Centre which is continually expanding its services? This is a great opportunity to develop your cli ...
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Chief Cardiac Physiologist
1 week ago
West Suffolk NHS Foundation Trust Bury St Edmunds, Suffolk, United KingdomAre you looking for a new and exciting challenge? Are you committed to delivering the best and safest care to patients? Would you like to work in a dedicated Cardiac Centre which is continually expanding its services? This is a great opportunity to develop your clinical skills, p ...
PhD Studentship: Computational Modelling of Transcatheter Aortic Valve Implantations - Cambridge, United Kingdom - University of Cambridge
Description
Background: The heart has four valves that work together to ensure unidirectional flow of blood. These valves are the aortic and mitral valves on the left side, and the pulmonary and tricuspid valve on the right side. Heart valve disease is when one or more of these valve do not function as they should, for instance the valve may not open fully (valve stenosis) or close fully (leaky valve or valve regurgitation). Aortic valve stenosis is one of the most common and serious heart valve diseases that, if left untreated, may lead to heart failure. Aortic valve replacement is used to treat affected patients ¿ this involves replacing the diseased valve with a prosthetic valve made from synthetic materials (e.g. mechanical valve) or animal tissue (e.g. bioprosthetic valve). Transcatheter aortic valve intervention (TAVI) has emerged as non-invasive alternative to surgical aortic valve replacements (SAVR). It was initially developed for patients at high surgical risk but is now being used for in younger patients with low surgical risk, raising concerns about its long-term durability compared to SAVR.
Objectives: Understanding the fluid dynamics and biomechanical interactions between the TAVI device and patient anatomy is critical for reducing the risk of adverse clinical outcomes. This project will use computational fluid dynamics (CFD), finite element analysis (FEA) and fluid-structure interaction (FSI) with patient-data to provide insights into the development and progression of adverse outcomes associated with TAVI and valve-in-valve procedures, including thrombosis, coronary obstruction, and paravalvular leakage.
Informal enquiries can be addressed to Dr Shelly Singh-Gryzbon,
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
