Associate Principal Scientist, Protein Scientist - Cambridge, United Kingdom - Bicycle Therapeutics

Bicycle Therapeutics

Verified Company

Cambridge, United Kingdom

1 week ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

Company Description
Bicycle Therapeutics (

NASDAQ:
BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines.

Our pipeline includes Bicycle Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need.

Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

We are
Adventurous. We believe it's the way to deliver extraordinary results for our patients.
We are
Dedicated to our Mission. You can't change the world if you don't have determination.
We are
One Team. We only succeed when we work together.

Job Description:

We have an exciting opportunity for a highly skilled Associate Principal Scientist to join our Protein &

Cellular Sciences Team:

You will join a small team dedicated to acquisition and production of high-quality recombinant protein material to facilitate the Bicycle discovery platform.

Key responsibilities

Support multiple Discovery campaigns by acting as key point of contact for stakeholders, understand project requirements, provide scientific guidance on proteinrelated matters
Research target biology and identify necessary reagents to progress programs
Design, express, and purify recombinant proteins using eukaryotic & prokaryotic systems
Organise and direct work with CROs as appropriate to diversify/increase throughput
Drive scientific excellence in the team by championing process improvements, help the team imbed best practice, review data generated by the team and develop SOPs as needed
Management of our protein quality control process including summarising your own and other peoples BLI, mass spectrometry, SDS-PAGE & SEC-MALS data.
Collaborate with our informatics team to further integration of protein quality control data into electronic lab notebooks and relevant reporting systems, working with the database manager to add or improve functionality where necessary, automate processes where possible and facilitate data sharing across functions
Independently problemsolve, troubleshoot, and identify next steps and solutions
Present interpreted data and conclusions of independently conducted research effectively in oral or written form to internal team and external partners, including possible next steps to drive projects forward
Interact and communicate efficiently in a collaborative environment involving crossfunctional teams of biologists and chemists
Organise, plan and coordinate work with broader protein sciences team

Qualifications*Essential:

Relevant academic or industry experience with a focus on protein science
Extensive experience in a biotech or industrial environment
Comprehensive understanding of molecular biology and protein production from eukaryotic and prokaryotic systems including antibody production
Extensive practical experience in protein purification with AKTA systems including affinity chromatography, HIC, IEX, and SEC
Handson experience of a range of biophysical and/or biochemical assay techniques to characterise protein function, including BLI, SPR and SEC-MALS
Experience managing projects or processes
Ability to prioritise and adapt work to facilitate delivery to timelines
Strong interpersonal skills along with data presenting & reporting
Diligent in documenting work and adherent to data integrity requirements

Desirable:

A PhD in Biochemistry with a focus on protein science
Experience in DNA assembly methods
An understanding of structural biology
Ability to interpret mass spectrometry data
An understanding of phage display or other display technologies
Prior experience of line management (if line management is desired)

Additional Information

Stateoftheart campus environment with on campus restaurant and Montessori nursery
Flexible working environment
Competitive reward including annual company bonus
Employee recognition schemes
28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
Employer contribution to pension (employee does not have to contribute)
Life assurance cover 4x basic salary
Private Medical Insurance, including optical and dental cover
Enhanced parental leave policies
Group income protection
Employee assistance program
Health Cash Plan
Access to company subsidized gym membership
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not dis