Target Discovery Imaging Scientist - Stevenage, United Kingdom - Taleo BE

Description

385176 Target Discovery Imaging Scientist (Senior Scientist/Investigator)

Our Target Discovery department at GSK is comprised of several disciplines that provide the deep scientific knowledge and technical capabilities required to discover and validate potential novel therapeutic targets through the application of extensive genetic analyses, high throughput genome editing and endophenotyping in well-characterized human cellular and in vivo models.

Drawing on genotypic and phenotypic databases from our world-leading partnerships with the UK BioBank and by interrogating the genome through internal and collaborative efforts with the Altius Institute, Open Targets, and the Laboratory of Genomics Research (LGR) with CRISPR pioneers Jennifer Doudna and Jonathan Weissman at the University of California, we aim to redefine how the industry approaches drug discovery to deliver transformative medicines for our patients.

An exciting opportunity is available within Target Discovery for a motivated senior scientist or scientific investigator to apply expertise in high content imaging and other phenotypic endpoints to functional and chemo- genomic screens to identify new, high-quality, de-risked drug targets. The successful candidate will work as a part of the global Imaging Team within the Imaging & Automation group in Genome Biology as well as with colleagues from other Research Technologies groups (including Human Genetics & Genomics, Large Molecule Discovery, Molecular Modalities Discovery, Pre-Clinical Sciences, and Data and Predictive Sciences), AI/ML, Research Statistics, and the Therapeutic Areas to design, execute, and analyze imaging endpoints in target discovery and validation screens. Additionally, the successful candidate will contribute to new capability developments that allow the team to stay on the cutting edge of high content drug discovery.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

• Independently design, implement, analyze, and interpret high content imaging assays to support multiparametric large-scale target identification arrayed screening across multiple disease areas (i.e. oncology, immunology, infectious disease).
• Work in an international matrix team environment to drive timely delivery of project and department objectives to the highest scientific standard.
• Maximize information content derived from imaging readouts through internal collaboration with AI/ML and Research Statistics teams.
• Clearly record in electronic lab notebooks and communicate study results at internal and external meetings.
• Contribute to the development of high content imaging community within Target Discovery and more widely within GSK.
• Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies.
• Comply with all standards and practices of data integrity, ethics, and safety.
• Model GSK's values of patient-focus, respect, transparency, and integrity.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• BSc in biology, biomedical engineering, bioengineering or other relevant life-sciences related degree with significant and varied professional experience working in a research or pharmaceutical setting; OR MSc/PhD in biology, biomedical engineering, bioengineering or other relevant life-sciences related degree with some professional experience working in a research or pharmaceutical setting
• Extensive experience in confocal microscopy, high content imaging, image analysis
• Experience with standard image analytics, secondary analysis packages, and data visualization tools (i.e. Image J/FIJI, Columbus/Harmony, Spotfire, Genedata Screener, etc). to analyze data from high content imaging screens
• Basic biology experience (i.e. cell culture, supporting assays)
• Ability to independently design, execute and interpret high-quality experiments.
• Strong communication skills; comfort presenting both virtually and in person
• Proven track record of teamwork, adaptability, innovation, initiative, and integrity.
• Builds strong relationships with peers and cross functionally with partners outside of the immediate team to support and influence projects.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Fluent in 1 or more programming language; ability to write and run custom analysis scripts and debug code written by others. Experience with machine learning a plus.
• Experience running high throughput, high content screens (i.e. understanding of screening best practices, experience using automated liquid handling platforms).
• Previous experience in biotech and/or pharmaceutical drug discovery.
• Experience with PerkinElmer/Revvity, GE/Cytiva/MolecularDevices, or Yokogawa high content imaging systems.
• Understanding or use of CRISPR technology.
• Experience with complex or 3D cellular models (stem cell platforms, organoids/spheroids, microfluidic devices)
• Experience working with primary immune cells, particularly in a screening context.
• Experience with high throughput flow cytometry and cell sorting.
• Evidence of leading new technology initiatives, working with commercial partners to evaluate and implement new technologies relevant to high content imaging.

Closing Date for Applications – December 20th, 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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