In Vivo Immunologist - Oxford, Oxfordshire, United Kingdom - Allergan

Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.

We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio.

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Based at the vibrant research community of Oxford.
Comprehensive benefits package.
Amazing career opportunities in a growing division with exceptional training.

At DJS Antibodies, we aspire to create new medicines to improve the lives of patients with serious immunological diseases and cancers.

As a biotech company within AbbVie, we combine the agility, team spirit and scientific focus of a biotech with the reach and vision of a global pharmaceutical company.

This role will span mechanistic biology, pharmacology, target selection and antibody discovery.

The primary focus will be to develop an understanding of the background biology and signal transduction pathways of the proteins targeted by candidate antibodies, and then designand conduct experiments using in vivo and in vitro systems to dissect the pharmacology and mechanism of action of the candidate antibodies.

There will also be a role to play in the antibody discovery process, particularly implementation and development of our animal immunization technologies.

The successful applicant should have a track record of immunology research in industry or academia.

Day-to-day, they will work collaboratively in project teams who are focussed on different programs at different stages of the R&D process.

They should therefore be keen to get involved with all aspects of research at DJS. At DJS, we want to foster innovative scientists performing drug-discover led by cutting-edge science.

In this role the successful candidate will develop knowledge across mechanistic biology, pharmacology, and early discovery with visibility across our portfolio of early discovery through to clinical-stage drug candidates.

As such this role will bring many career development opportunities.

These are extended further by our unique position within AbbVie, which allows access into a much broader, world-leading drug development pipeline and learnings about broader pharmaceutical business.

Establish and implement in vivo and in vitro experimental models for assessing antibody pharmacology and mode of action
Work closely with the animal project licence holder to design study plans and keep meticulous records of in vivo experiments
Engaging with the literature to build deep understanding of target biology
Perform critical laboratory experiments and analysis to develop and extend existing methodologies
Mentor junior scientists from the bench side in new and novel immunological techniques and methodologies
Gather, analyse and present data from a variety of sources to the wider team and organization
Critical and impartial review of self- and peer-generated laboratory data to create tangible actions
Maintenance of laboratory experimental records
A PhD in Immunology or a related field or equivalent level of experience
Have a passion for in vitro and in vivo immunology and translational biology
Enthusiasm and commitment to drug development research
Secondary ex vivo cell-based assays (such as, for example, FACS/cell sorting, imaging, ELISA/MSD, Western-blot and omics-based approaches such as RNA-seq)
Statistical analysis, power calculations and experimental design

Building and maintaining collaborative networks of researchers across multiple organisations
Working within an industrial setting on a drug development program
Working with contract research organisations
Laboratory method development
Ability to work flexible hours when required
Flexible and adaptable with an all-inclusive goal-orientated mindset

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.

It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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