Postdoctoral Research Scientist or Research Assistant - Cambridge, United Kingdom - Babraham Institute

Description

We are seeking a Postdoctoral Research Scientist or Research Assistant with a background in immunology and/or molecular biology to lead an exciting new collaboration between the labs of Arianne Richard (Immunology Programme) and Peter Rugg-Gunn (Epigenetics Programme) at the Babraham Institute. Combining the expertise of these two groups, the recruited scientist will investigate the role of epigenetic memory in guiding functional divergence of particular T cell subsets dependent on stimulation history. This project will specifically test whether differentiation and functional responses of effector T cells are impacted by epigenetic memory in their precursor states. To this end, the appointed scientist will i) Compare the epigenetic and functional properties of effector T cells and precursors with different stimulation histories; ii) Test and refine an in vitro system to interrogate causal relationships between epigenetic modifications and T cell effector function.

The exciting implication of this work will be to generate new insight into how prior experiences within a T cell lineage shape effector responses and whether this behaviour is encoded by epigenetic memory. This is important because T cell-intrinsic effects of prior exposures have the potential to contribute to differences in immune responses that accumulate over the lifecourse. In addition, characterising the epigenetic effects of stimulation history can ultimately influence the rational design of T-cell-targeting vaccination.

The successful candidate will lead this project, designing, carrying out and analysing experiments with input and training from both supervisors and their teams. The post holder will have the opportunity to disseminate their research through conference presentations and publications, train students, expand their skills and network through established collaborations, and benefit from engagement with the Babraham Institute's world-leading scientific community.

The ideal candidate will have relevant research experience, which may include immunology or molecular biology, and will have experience with in vivo or in vitro work with lymphocytes. In the case of a postdoctoral candidate, this will include a PhD in a relevant discipline. The post involves working collaboratively across two teams, and so excellent communication skills are essential.

This is a limited term appointment with funding for this post available for a period of one year. We anticipate applying for additional grant funding during the course of the project, which if successful could be used to extend the duration of this position. Although this position is advertised as full-time, we also welcome enquiries and applications from individuals who wish to be considered for part-time working arrangements.

A full job specification and role requirements can be found attached to this vacancy.

Informal enquiries can be addressed toArianne Richard ( ) or Peter Rugg-Gunn ( ).

For more information on the work of the groups, please visit:

Applicants for the Postdoctoral Research Scientist position must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £33,500 per annum, if you have not yet been awarded your PhD. All newly appointed postdocs will commence on the salary/scale point that reflects the number of years' post-PhD experience they hold on 30th June in the calendar year they commence employment.

Closing date for applications is Friday, 26th April 2024.