Principal Scientist: Pharmacometrics - Alderley Edge, United Kingdom - SRG

Description

Job Description

Are you a Pharmacometrics expert looking to make your mark across the pharmaceutical sector whilst working for a well renowned, exciting CDMO focused on solving complex pharmaceutical problems for their customers?

Job Title: Principal Scientist - Pharmacometrics Expert

Type: Permanent

Salary: Highly attractive

Location: Northwest, England

SRG is currently working exclusively with a highly successful, award winning, contract development and manufacturing organisation focused on providing expert intelligence and support to their partners, driven by their capabilities.

As a result of expansion and a significant increase in workload, we are looking for an expert in Pharmacometrics to join the DMPK team.

Typical responsibilities/accountabilities:

• scientific and pragmatic design thinking to contribute to the delivery of candidate drugs and/or development plans, documentation, data interpretation and decisions for Clients' compounds and products as required (across the whole portfolio).
• as project leader for client projects, providing strategic and scientific PK/PD and biopharmaceutics advice across all stages of discovery and clinical development.
• to the design, analysis, and interpretation of non-clinical and clinical pharmacology studies.
• human PK and dose prediction through application of pharmacometric principles and analysis.
• PK/PD analysis and population PK and PBPK modelling and simulation.
• PK/PD sections of regulatory documents, including INDs, NDAs, briefing packets, Investigator Brochures, etc.
• current knowledge of advancements in DMPK and PK/PD science, regulatory guidance documents, FDA rulings, internal SOPs, and internal working practices to be able to contribute ideas to improve technologies and procedures for PK practice.
• of the financial aspects of projects with clients, such as costing proposals and invoicing.
• at national and international meetings / conferences to build the reputation and awareness of the company
• business development material such as white papers and technical communications for online posting and attend trade/partnering events

Essential Requirements:

• PhD and significant experience across pharmacometrics / pharmacokinetics / clinical pharmacology or Bachelors degree and significant industrial experience of leading.
• Expertise in PK/PD modelling with strong quantitative skills applied to develop models with nonlinear behaviour, mechanistic or semi-mechanistic components relating to mechanism of action and tailored to meet specific drug-development questions.
• Will be an expert in population Pharmacokinetic and Pharmacokinetic/ Pharmacodynamics modelling.
• Modelling experience (e.g., popPK and PK/PD analyses, model-based meta- analysis, dose-response and exposure-response analyses, dataset creation, disease modeling, trial simulation, optimal study designs, strategic decision analyses, economic modelling).
• Technical and programming skills with population analysis and other software, including NONMEM and R as a minimum. Experience with Monolix and PKSim is a plus.
• of ability to develop drug products and documentation that meet clinical and regulatory requirements.
• to apply scientifically sound principles efficiently in the analysis and interpretation of PK/PD data is a necessity.
• UK driving license

SRG are the UK number 1 recruitment company specialising in the science, engineering, clinical, pharmaceutical, food/FMCG, renewable, biotech, chemicals and medical devices sectors.

As scientists ourselves, our specialist sector knowledge and our passion are second to none. It's this combination that makes us different. We're committed to providing outstanding temporary, contract and permanent career opportunities of all levels for our candidates and a comprehensive range of expert strategic recruitment services for our clients.

If you would like to apply for this position, please use the link provided. Alternatively please email a copy of your CV to Selby at For more information regarding this position or any others, please call Selby on

If you have a scientific background and this position is not relevant / suitable for you please feel free to get in touch or visit to view our other vacancies.