Quality Management Lead - London, United Kingdom - myGwork

Description

This inclusive employer is a member of myGwork – the largest global platform for the LGBTQ+ business community.
Leader of DMPK and Physical Sciences
, Isomorphic Labs is a new Alphabet company that is reimagining drug discovery through a computational- and AI-first approach.

You'll be working at the cutting edge of the new era of 'digital biology' to deliver a transformative social impact for the benefit of millions of people.

This is an exciting opportunity to work closely with world leading AI and ML experts to develop imaginative new ways to predict ADMET and human dose to drive projects forward.

We are seeking a candidate who is highly experienced, with significant management experience, working across drug discovery projects, driving them to Candidate Selection and preferably to clinical phases of development.

Set the company DMPK strategy across the project portfolio
Lead a small team of DMPK scientists to deliver on Drug Discovery projects
Work with CROs to deliver the highest quality ADMET data and reports
Distil ADMET data into actionable insights for project leaders, project team members, and potential collaborators
Be closely integrated in projects to provide strategic input into the project direction
Prepare relevant internal and regulatory documentation for preclinical and clinical work
Work cross functionally with Medicinal Chemistry, Biology, and Technology groups
BSc, MSc or PhD in Biochemistry/Chemistry/Pharmacology/Pharmacokinetics and likely be highly experienced (
10 years) in the pharmaceutical industry
Expert knowledge are DMPK concepts such as Tier 1/2 ADMET assays, Transporters, Drug Metabolising Enzymes and Transformations, IVIVC/IVIVE, Pharmacokinetics, PK-PD relationships, mechanistic and allometric scaling approaches to Human Dose Projections
Proven track record of influence on projects such as de-risking strategies, anticipating longer term issues, solving ADMET issues and driving change in Medicinal Chemistry SAR strategies
Experience working with Toxicology, Translational, Formulation, Clinical Pharmacology in setting clinical strategies
Driven and focussed mindset to achieve the goal of Candidate delivery in the most efficient manner through robust discussions with key stakeholders and project leaders
Dynamic, agile, and flexible individual who can work across therapeutic areas, and multi-disciplinary teams
Experience working with and assisting CROs in acquiring high quality ADMET data in a timely manner
Knowledge/Concept of computational chemistry machine learning modelling
Good understanding of Medicinal Chemistry concepts and comfortable discussing small molecule approaches and strategies
Experience working with Data Science groups in setting up assay templates for ingestion of ADMET data
It is about good people doing good, rigorous and future-making science every single day.
Together at Iso is about connection, collaboration across fields and catalytic relationships.

It's knowing that transformation is a group project, and remembering that what we're doing will have a real impact on real people everywhere.

We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.

If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.
Hybrid working
This is why we've decided to follow a hybrid model, and for full time positions we would
require you to be able to come into the office 3 days a week
(currently Tue, Wed, and one other day depending on which team you're in). For part time positions this may vary.
As an equal opportunities employer we are committed to building an equal and inclusive team.

If you have additional needs that would prevent you from following this hybrid approach, we'd be happy to talk through these if you're selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.

Click to view other open roles at Isomorphic Labs