Research Scientist - Oxford, United Kingdom - Isogenix Inc

Description

Job Description

Research Scientist

Are you driven by the potential of gene therapy to transform lives and eager to be at the forefront of this revolutionary field? Look no further Our dynamic start-up is seeking a talented and motivated entry- to mid-level research scientist to join our growing team of brilliant minds.

Important: We only accept applications through email (see below). We kindly request that you refrain from sending Linkedin direct messages, as we will only be responding to emails.

About ISOGenix

We are an early stage, Oxford University spinout from Prof. Matthew Wood, Dr. Carlo Rinaldi, and Dr. Catheryn Lim's research, currently based in Oxford, UK. Using a proprietary approach, we are developing precision therapies to harness the therapeutic potential of protein isoforms for the treatment of serious diseases with significant unmet medical need. We are backed by an established venture capital investor and have a clear mission to improve lives through genetic medicine. Our approach combines advanced research, state-of-the-art technologies, and a strong team of founding members with decades of experience in the field of cell and gene therapy.

Responsibilities

As a research scientist at ISOGenix, you will be at the heart of our ground-breaking gene therapy research. Collaborating with a team of dedicated scientists and experts, you will contribute your expertise to advance our innovative projects. Your key responsibilities will include:

• Developing effective in vitro molecular assays for transcript and protein isoform validation and characterisation in various cell lines.
• Production and purification of adeno-associated viral vectors (AAVs) using mammalian cell culture systems (i.e.HEK293) for use in preclinical gene therapy program development.
• Conducting laboratory analyses of AAVs using SDS-PAGE, qPCR, digital droplet PCR, flow cytometry/ FACS, ELISA, gel electrophoresis, TEM etc.
• Providing support to new technology and therapy development and innovation programmes.
• Day-to-day management of own research and administrative activities.
• Independently analysing and interpreting data, preparing detailed reports, and presenting research findings at internal meetings.

Qualifications

To excel in this role, you should possess the following qualifications and skills:

Essential

• A PhD (or at least a master's degree with experience) in biotechnology, molecular biology, biochemistry, genetics and genomics, or related discipline.
• Experience in molecular biology techniques and laboratory analysis including cloning, gene and protein expression assays, cell culture, SDS-PAGE and flow cytometry.
• Extensive AAV biology and production experience using HEK293 cells.
• Experience in the area of genetic therapy including AAV and/or genome editing based therapies.
• Self-motivated and able to work independently within a small dynamic team.
• Have an organised and methodical approach to implementation of experimental procedures; keep accurate records.
• Excellent verbal and written communication skills, including the ability to write protocols, reports and publications and present research findings to internal meetings.
• Experience of working collaboratively within a team and with external collaborators.
• Ability to work in a fast-paced environment and deliver high quality data within deadline-driven workflows.
• IT skills, data management skills and presentation skills.

Desirable

• Drug discovery or drug development experience in an academic, biotech or pharmaceutical company setting.
• Knowledge/ experience in next generation/ third generation long-read sequencing; experience in human genomics.

Benefits

We value our employees and are committed to creating an inspiring and supportive work environment. As a research scientist, you will enjoy:

• The opportunity to work alongside a talented and passionate team of researchers (from ISOGenix and Oxford University) and industry experts.
• Access to cutting-edge laboratory facilities and state-of-the-art gene therapy technology.
• Competitive salary/ compensation package.
• A healthy work-life balance.
• Continuous professional development and learning opportunities.
• The chance to be part of a genetic medicine revolution that can change lives.
• The opportunity to be an early team member of an exciting new biotech start-up.

How to Apply (IMPORTANT)

Please submit your resume and a cover letter explaining your interest in the position to We are excited to review your application We will be reviewing applications on a rolling basis and aim to fill the position promptly. Therefore, we encourage qualified individuals to submit their applications without delay.