- You will perform high-throughput screening experiments on mutant libraries to map the importance of each amino acid in the GLP-1R and the CGCR for cholesterol binding.
- You will also participate in the development of a new method to apply a directed evolution approach based on vaccinia virus libraries to generate evolved receptors with the desired cholesterol binding capabilities.
- PhD in molecular cell biology or related subject.
- Previous experience in glucagon receptor subfamily.
- Previous experience in studying GPCR – lipid interactions.
- Experience in validating receptor cholesterol binding sites.
- Previous experience in pancreatic beta cell and islet biology.
Research Associate - London, United Kingdom - Imperial College London
Description
Location: Hammersmith Campus
Job Summary
We are looking for a PhD graduate to join our group in order to map actionable cholesterol binding sites in the glucagon-like peptide-1 receptor (GLP-1R) and in the glucagon receptor (GCGR), using state-of-the-art high throughput screening techniques including deep mutational scanning coupled with mass-spectrometry analysis and directed evolution approaches.
Duties and responsibilities
Essential requirements
Further Information
This post is full time, fixed term for 2 years and you will be based at Hammersmith Campus.
Should you require any further details on the role please contact: Dr Alejandra Tomas – a.tomas-
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £40,694 - £43,888 per annum.
Hybrid working may be considered for this role. Staff working in roles that are suitable for hybrid working will normally be expected to work 60% of their time onsite. The opportunity for hybrid working will be discussed at interview.
More information is available on the following web page: Work Location Framework | Administration and support services | Imperial College London
Closing date: 25 April 2024
£45,593 to £53,630 p.a.