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Dundee

    KOODAC Team Structural Biologist - Dundee, United Kingdom - University of Dundee

    University of Dundee
    University of Dundee Dundee, United Kingdom

    6 days ago

    Default job background
    Full time
    Description

    We are recruiting for an exceptional Structural Biologist / Biophysicist with experience in studying structures of protein- ligand and protein-protein complexes to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic, multi-disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer Grand Challenges, within KOODAC ). KOODAC's mission is to discover and develop small-moleculedrugsthat degradekeyoncogenicdriversofsolidtumoursinchildren , as a novel therapeutic paradigm to treat pediatric cancers. The team will develop two types of degraders - proteolysis targeting chimeras (PROTACs) and molecular glue degraders. Both classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce target's ubiquitination and degradation, leading to cell death. The team will focus on developing degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive rhabdomyosarcoma, respectively, in children.

    Candidate Requirements:

  • A Ph.D. in structural biology, biophysics, biochemistry, chemical / molecular biology, or a related discipline
  • Highly experienced in molecular biology (construct design, cloning etc.), protein expression, purification and characterisation.
  • Strong experience in structure solution and model refinement via protein X-ray crystallography and/or cryo- EM.
  • Outstanding academic and/or industrial track record.
  • Excellent interpersonal, communication and presentation skills.
  • Capable of working in a diverse team, but able to plan and work independently.
  • Exceptional time management, organisational and self-motivational skills.
  • An open and collaborative approach to science.

    • Preferred skills:

  • Experience with biophysical techniques and assays to study protein-ligand and protein-protein interactions are strongly desired.
  • Experience with studying of PROTACs and/or molecular glue degraders.
  • Experience with studying protein-ligand interactions and structure-based drug design.

    • For further information about this position please contact Professor Alessio Ciulli at To find out more about Group please visit the group's Website.

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