Postdoctoral Research Associate in Epigenetics and - Oxford, United Kingdom - University of Oxford

University of Oxford

Verified Company

Oxford, United Kingdom

2 weeks ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

Pay Scale:
STANDARD GRADE 7

Salary:
£36,024 - £41,732 per annum

Location:
Department of Biochemistry, South Parks Road, Oxford

Contract type:
Fixed Term Contract for up to 3 years

Hours:
Full Time (37.5 hours per week)

THIS IS A READVERTISEMENT AND PREVIOUS APPLICANTS NEED NOT APPLY

About the role
We are seeking to appoint a Postdoctoral Research Associate to join the lab of Professor Peter Sarkies.

Transgenerational epigenetic inheritance is increasingly recognised as a way in which changes in gene expression can be passed across multiple generations without changes in underlying DNA sequence.

Mechanistic characterisation of transgenerational epigenetic inheritance is most advanced in the nematode C.

elegans, where transgenes can be silenced by small non-coding RNAs (sRNAs) and the silent state transmitted for multiple generations independent of the initial trigger.

Could such epigenetic changes contribute to evolutionary processes as well? This project aims to find this out.

It builds on prior work from the lab showing that "epimutations"- spontaneous changes in epigenetic states, can arise spontaneously in C.

elegans populations and be transmitted for a limited number of generations.

We now want to test whether these epimutations could drive evolutionary processes, in particular whether the evolution of resistance to antihelminthic drugs such as Ivermectin can be promoted by epigenetic changes.

We will evolve resistance to Ivermectin in the lab by conducting long term evolution experiments using C. elegans.

We will follow the trajectory of gene expression, small RNAs and chromatin using high throughput sequencing across the timecourse of adaptation to identify epimutations that may promote resistance.

This project has the potential to redefine our understanding of the mechanisms of evolution and could prove important in tackling resistance to antihelminths in parasitic nematodes.

The project is fully funded for three years by the Leverhulme Trust.

This full-time fixed-term post is funded by the Leverhulme Trust for up to 3 years in the first instance.

The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available.

What We Offer
Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including:

An excellent contributory pension scheme
38 days annual leave
A comprehensive range of childcare services
Family leave schemes
Cycle loan scheme
Membership to a variety of social and sports clubs
Discounted bus travel and Season Ticket travel loans

The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work.

About you

Application Process
If you would like to discuss this role, please contact Peter Sarkies

**Committed to equality and valuing diversity