- Apply computational chemistry methods and tools to accelerate the discovery and development of drug candidates, in close collaboration with chemists, structural biologists, biologists and other project scientists
- Leverage physics-based methods, generative models and machine learning approaches to design new chemical entities
- Contribute to the further development of Vertex's computational chemistry capabilities with a focus on physics-based method (e.g. FEP, ABFE, QM)
- Use timely decision making to ensure focus and delivery of key project objectives. Promote high levels of productivity and urgency
- Proactively work with other computational chemists and cheminformaticians to assess and develop new computational methodologies, create workflows and share successful methods
- Seek out opportunities to improve Vertex's global R&D capabilities through collaboration with DMPK, Structural Biology, safety assessment, and other groups
- In depth knowledge of physics-based methods and the state-of-the-art in computational chemistry and their application in drug discovery
- Experience with commercial and/or open-source molecular modeling and data mining software
- Knowledge of concepts related to drug discovery and development
- Strong solution-oriented attitude, spirit of innovation and creativity, good time and priority management
- Scripting and programming expertise in languages such as Python
- Excellent interpersonal, communication and presentation skills
- Ph.D in Computational Chemistry or related discipline or equivalent combination or education and experience.
- Post-doctoral employment and experience in drug discovery is required
- Experience in applying a wide array of molecular modeling methods to structure, ligand and fragment-based drug discovery projects
-
Postdoctoral Research Associate in Drug Design
3 weeks ago
University of Oxford Oxford, United Kingdom**Pay Scale**: STANDARD GRADE 7 · **Salary (£)**: £36,024 - £44,263 per annum · **Location**: Department of Biochemistry, South Parks Road, Oxford · **Contract type**: Fixed Term Contract up to 16th April 2025 · **Hours**: Full Time (37.5 hours per week) · **About the role** · We ...
-
Postdoctoral Research Associate in Drug Design
1 month ago
University of Oxford Oxford, United Kingdom Full time, Fixed-Term/ContractLocation: South Parks Road, Oxford · We are seeking to appoint a Postdoctoral Research Associate to join Prof Philip Biggin's lab in collaboration with Boehringer Ingelheim (BI) to investigate and establish novel methods for protein-ligand affinity prediction that can offer signi ...
-
University of Oxford Oxford, United KingdomWe are seeking to appoint a highly motivated Research Assistant to join the Oxford Drug Discovery Institute team led by Professor Paul Brenan at Centre for Medicines Discovery. The Research Group is a part of a world-class network of three drug discovery institutes sponsored by A ...
-
Director of Medicinal Chemistry Remote-based
3 weeks ago
Science Solutions Recruitment Ltd Oxford, United KingdomThis is a great job opportunity for an experienced medicinal chemist with proven industrial drug discovery expertise to step out of the laboratory into this home-based Director of Medicinal Chemistry position at a multi-national biotech firm with a UK office.The Director of Medic ...
-
Structural Biologist
3 weeks ago
Exscientia Oxford, United Kingdom**As a Structural Biologist (cryo-EM) you will have the opportunity to**: · - Solve structures of ligand-protein, protein-protein, and antibody-antigen complexes in a cryo-EM pipeline that will be integrated within Exscientia's AI-driven design and automation platform for Biologi ...
-
Senior Dmpk Project Leader
3 weeks ago
Proclinical Oxford, United KingdomProclinical are recruiting a Senior DMPK Project Leader for a biotech organisation. This role is on a permanent basis and is located in Oxford with the ability to work either on a hybrid or remote basis. The client is focused on discovering smarter and faster ways to find innovat ...
-
Postdoctoral Research Associate in Medicinal
3 weeks ago
University of Oxford Oxford, United KingdomApplications are invited for a Postdoctoral Research Associate to work on a research project entitled "Second generation arylhydrocarbon receptor antagonist, utrophin modulators for the treatment of Duchenne muscular dystrophy", working under the supervision of Professor Angela R ...
-
University of Oxford Oxford, United KingdomWe are seeking to appoint a highly motivated and dedicated Postdoctoral Researcher in Pharmacoepidemiology and Pharmacogenetics to join the research groups led by Professor Daniel Prieto-Alhambra at the Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and ...
-
Drug Practitioner
3 weeks ago
Sanctuary Health Oxford, United KingdomSanctuary Personnel invites you to discover an exciting role that could be the perfect fit for you. As a dedicated and award-winning recruitment agency with a remarkable TrustPilot score of 4.8/5 and over 500+ reviews, we are committed to connecting talented professionals like yo ...
-
Executive Director, Structural Biology
2 weeks ago
Exscientia Oxford, United Kingdom Full timeAbout Us · Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment ...
-
Senior Research Scientist in Molecular
4 days ago
Talent Works Oxford, United KingdomSenior Research Scientist in Molecular & Cell Biology - For Stem Cell biologist · Maternity cover (15 month contract) · Our Human Disease Modelling group is seeking an innovative and dynamic Research Scientist to play an important role in expanding our capabilities at the Oxford ...
-
Exscientia Oxford, United Kingdom Full timeAbout Us · Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment ...
-
Exscientia Oxford, United Kingdom Full timeAbout Us · Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment ...
-
Molecular & Cell Biology Research Scientist
4 days ago
Talent Works Oxford, United KingdomMolecular & Cell Biology Research Scientist, Maternity Cover · Our Human Disease Modelling group is seeking an innovative and dynamic Research Scientist to play an important role in expanding our capabilities at the Oxford Research site. The successful candidate will help us uti ...
-
Research Scientist, Immunology
2 weeks ago
Exscientia Oxford, United Kingdom Full timeAbout us · Exscientia is an AI-driven precision medicine company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide t ...
-
Lead Clinical Scientist
6 days ago
Hays Specialist Recruitment Limited Oxford, United Kingdom Full timeYour new companyYou'll be joining an innovative biotech company who are further expanding their team after a large funding round is expanding to support the Clinical Development of their pipeline as they move their lead asset into Phase 1 trials. You'll be joining a highly experi ...
-
Postdoctoral Data Scientist
4 days ago
University of Oxford Oxford, United Kingdom Full timeNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD We have an exciting opportunity for Postdoctoral Data Scientist to join a Pharmaco- and Device epidemiology research group led by Professor Dani ...
-
University of Oxford Oxford, United Kingdom Full timeNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Windmill Road, Oxford, OX3 7LD We have an exciting opportunity for a Postdoctoral Researcher in Real World Evidence to join our Pharmaco- and Device epidemiology research grou ...
-
Receptionist/Administrator
2 weeks ago
Oxford Health NHS Trust Oxford, United Kingdom PermanentJob summary · An opportunity has arisen for an enthusiastic and innovative Receptionist/Administrator who has an interest in services for homeless people. · The nature of this key role is often challenging and demanding, you will require skills to handle all contacts confidently ...
-
Senior Clinical Quality Assurance Specialist
2 weeks ago
Jazz Pharmaceuticals Oxford, United Kingdom Full timeBrief Description: · Prepare, perform, report and follow-up independent clinical quality assurance audits including associated quality management activities and provide input into the audit schedule. Acts as Lead auditor as applicable. To support Clinical Quality Assurance in it ...
Senior Research Scientist, Computational Drug Design - Oxford, United Kingdom - Vertex
![Default job background](https://contents.bebee.com/public/img/bg-user-ex-1.jpg)
Description
Job Description
General Summary:
We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Oxford. This individual will be responsible for contributing to both hit/lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively with the global Data and Computational Sciences group to provide expertise in data analysis, cheminformatics, and physics-based methods development. Thus, this individual must demonstrate strong interpersonal skills and have demonstrated the ability to guide scientists in drug discovery.
Key Duties and Responsibilities:
Knowledge and Skills:
Education and Experience:
In this Hybrid-Eligible role, you can choose to be designated as:
Hybrid: work remotely up to two days per week; or selectOn-Site : work five days per week on-site with ad hoc flexibility.