Jobs

    PhD STUDENTSHIPS - Manchester, United Kingdom - Cancer Research UK Manchester Institute (CRUK MI)

    Cancer Research UK Manchester Institute (CRUK MI)
    Cancer Research UK Manchester Institute (CRUK MI) Manchester, United Kingdom

    3 weeks ago

    Default job background
    Full time
    Description

    4 Year PhD Studentship - Autumn 2024

    Cancer Research UK Manchester Institute

    Project Title: "Blocking proteins as a novel approach to treat blood cancer"

    Research Group: Leukaemia Biology

    Group Leader: Tim Somervaille

    This 4-year PhD studentship will be based at the Cancer Research UK Manchester Institute, New Paterson Building, Withington, Manchester, UK

    While there has been substantial progress in the treatment of blood cancers, there remains so much more to do. Many of our patients continue to present with incurable disease and so there is a substantial unmet need for better and less toxic therapies. This PhD project, based in Manchester at the Cancer Research UK Manchester Institute, will run jointly with colleagues at Dark Blue Therapeutics, a biotech company based in Oxford. The goal will be to evaluate the functional consequences and mechanistic basis of a new drug currently in development which blocks a critical protein involved in the transformation of normal stem and progenitor cells into leukaemia cells. To assess the potential activity of this drug, as the lead on this project you will perform in vitro cell growth assays of primary patient leukaemia cells collected direct from patients being treated with chemotherapy at The Christie NHS Foundation Trust. We share the same location as this hospital which is the largest single centre cancer hospital in Europe. You will also learn and develop in vivo assays to assess the consequences of drug treatment on patient cells in an in vivo mammalian model, as well as a wealth of cutting-edge molecular biology techniques appropriate to the project. This work builds on our recent experience and publications with new drugs which target proteins associated with chromatin (see for example Nicosia et al., 2023, Cancer Cell (EP300/CBP); Harris et al., 2012, Cancer Cell (LSD1); and O'Brien Laramy et al., 2023, Nature Reviews Drug Discovery) and sits at the leading edge of drug discovery and development in blood cancer.

    We are looking for a hard-working, enthusiastic, and ambitious person to join our friendly and interactive team. We would welcome applications from individuals with a strong academic track record and Masters-level and/or other laboratory research experience in leukaemia or cancer biology. Applicants should hold or expected to graduate with a first or minimum upper-second class undergraduate honours degree (or equivalent from a non-UK university) as part of a university degree course.

    The Cancer Research UK Manchester Institute is proud to be a diverse, open, and global Institute. Our priority, and that of the University of Manchester, is to support our current students and welcome new ones from Europe and other continents, we therefore encourage students of all nationalities to apply for the programme.

    Applicants can find full group details, and information on how to apply via the CRUK Manchester Institute's online PhD recruitment portal:

    Application deadline: Friday 17 May hrs (GMT)

    Interview date: Monday 17 June 2024, new Paterson Building, Manchester, UK

    Group Leader is

    Informal enquiries should be addressed to the Postgraduate Tutor at:

    We plan to hold in-person interviews however, we will take into consideration any change in circumstances at the time to ensure the safety of all concerned and we may amend the interview format to virtual if deemed necessary.


  • The University of Manchester

    PhD Studentship

    4 days ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Application deadline: All year round · Funding notes: · Industrial CASE, EPSRC supported by EDF Energy. · The candidate need to either be UK national or UK resident. · Proposed start date: 21/09/2024 to 01/01/2025 Duration of project/funding: 3.5 years · We are pleased to present ...

  • The University of Manchester

    PhD Studentship

    2 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This 3.5 year PhD is fully funded; home fees are included and a tax free stipend set at the UKRI rate (£19,237 for 2024/25). This project is for UK students only. The start date is 1st October 2024. · Nanoplastics, defined as plastic particles measuring less than 1000 nanometres, ...

  • The University of Manchester

    PhD Studentship

    3 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Funding is available for this 3.5 year PhD programme, funded by CoEBio3 Centre of Excellence in Biocatalysis (available for UK students and overseas). Funding will cover tuition fees and a tax free stipend set at the UKRI rate (£19,237 for 2024/25). The start date is September 20 ...

  • The University of Manchester

    PhD Studentship:

    1 week ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This 4-year PhD is fully funded for UK home students (by The University of Manchester), but only partial funding is available for overseas students. We will also provide a tax-free stipend set at the UKRI rate (£19,237 for 2024/25). The start date is October 2024. · The Robotics ...

  • The University of Manchester

    PhD Studentship

    3 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Title: Capillary pressure, relative permeability and wettability at critically-low saturated porous media (CRISP) · Application deadline: as long as possible until Dec 24 · Research theme: Porous Media Engineering, Subsurface Engineering, Experimental · Department: Chemical Engin ...

  • The University of Manchester

    PhD Studentship

    2 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Research theme: Digitalisation for Sustainable Construction · This 3.5 year project has EPSRC DTP funding. For UK students only, and EU students with settled status. Tuition fees will be covered and you will receive a tax free stipend set at the UKRI rate (£19,237 for 2024/25). T ...

  • The University of Manchester

    PhD Studentship

    3 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    How to apply: [] · This is a 3.5 year funded project open to UK students or EU students with settled status. You will receive a tax free stipend (depending on circumstances) set at the UKRI rate as a minimum (£19,237 for 2024/25). · A fully funded PhD position in multiscale mode ...

  • The University of Manchester

    PhD Studentship

    3 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This 3.5 year PhD is fully funded though CoEBio3; funding will cover fees and a tax free (depending on circumstances) stipend set at the UKRI rate (£19,237 for 2024/25). · Nucleotides are the building blocks of life, modulating diverse processes from protein production to cell si ...

  • The University of Manchester

    PhD Studentship

    3 weeks ago


    The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Department: Chemistry · Title: Understanding Fischer-Tropsch catalysts by in-situ spectroscopy · Application deadline: 01/05/2024 · Research theme: Catalysis, materials characterisation · How to apply: · This is an iCASE award funded through bp-ICAM. This 4 year PhD will start i ...


  • Manchester Metropolitan University Manchester, United Kingdom Full time, Fixed-Term/Contract

    Project summary · The management of chronic wounds poses a considerable burden on healthcare systems, with approximately 2.2 million patients currently afflicted, resulting in annual costs of £5.3 billion for the NHS to address wound care and its associated comorbidities, includi ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Proposed start date: 21/09/2024 Duration of project/funding: 4 years Studentship will provide fees and stipend at the UKRI rate for home students. Stipend for academic year 2024/25 will be £19,237. · We offer an exciting PhD opportunity in collaboration with Rolls-Royce, explorin ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This PhD is funded by the Department of Materials; tuition fees will be covered and a tax free stipend will be given based on the UKRI rate (£18,622 for 2023/24). · We are seeking a highly motivated and talented candidate to pursue a PhD in this exciting area of focused electron ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This PhD is funded by the Department of Materials. · Tuition fees will be covered and a tax free stipend will be given based on the UKRI rate (£19,237 for 2024/25). · We are seeking a highly motivated and talented candidate to pursue a PhD in this exciting area of focused electro ...


  • Manchester Metropolitan University Manchester, United Kingdom Full time, Fixed-Term/Contract

    Project summary · Rehabilitation services prove highly effective in managing numerous chronic conditions such as coronary artery disease, yet they remain underutilized among patients. Further, disparities in care are evident as the data indicates that women and individuals from s ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Hydrological modelling has a long legacy of development and as such there are a huge range of models to choose from for practical use. One of the key differences between hydrological models is the level of physical representation of catchment processes within the model code. Mach ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This 3.5 year PhD project is funded by the MADSIM Project, Funding is for Home students and EU students with settled status. Funding covers home tuition fees and provides a stipend at the UKRI rate (£19,237 for 2024/25). The start date is 1st October 2024. · This is an interdisc ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    Research theme: Applied Mathematics, Materials · This 3.5 year PhD project is funded by the MADSIM Project (School of Natural Sciences growth fund). Funding is for Home students and EU students with settled status. Funding covers home tuition fees and provides a stipend at the UK ...


  • Manchester Metropolitan University Manchester, United Kingdom Full time, Fixed-Term/Contract

    Project summary · The impact of alopecia is highlighted in the Global Burden of Disease estimates of years lost to disability, where alopecia areata (AA) was ranked higher than both psoriasis and melanoma in disease impact. · Irrespective of the underlying cause or pattern of the ...


  • Manchester Metropolitan University Manchester, United Kingdom Full time, Fixed-Term/Contract

    Project summary · The impact of alopecia is highlighted in the Global Burden of Disease estimates of years lost to disability, where alopecia areata (AA) was ranked higher than both psoriasis and melanoma in disease impact. · Irrespective of the underlying cause or pattern of the ...


  • The University of Manchester Manchester, United Kingdom Full time, Fixed-Term/Contract

    This 3.5 year PhD project is funded by the MADSIM Project, Funding is for Home students and EU students with settled status. Funding covers home tuition fees and provides a stipend at the UKRI rate (£19,237 for 2024/25). The start date is 1st October 2024. · This is an interdisc ...