Postdoctoral Researcher in Medicine - Oxford, United Kingdom - University of Oxford

University of Oxford

Verified Company

Oxford, United Kingdom

1 week ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

We wish to hire a talented and highly motivated molecular biology postdoc with expertise in protein production, folding and analyses to investigate the translational implications of mechanisms underlying human tissue T cell immune responses funded by the NIHR Biomedical Research Centre.

Graham Ogg's group is studying lipid-specific T cells in the blood and skin in order to define disease pathogenesis and to identify targets for future therapeutic intervention.

Samples are taken from well-characterised patients seen by Graham Ogg, as a consultant dermatologist.

Lipid-specific and peptide-specific T cells are isolated and analysed through single cell and bulk RNAseq in order to relate clonal T cell populations expressing individual TCR with associated functional responses.

The data will be used to characterise responses to novel antigens, as well as defining the responding T cells and TCR for future therapeutic development, including for inflammatory disease and cancer.

Tissue spatial protein and RNA expression analyses are also being actively pursued.

The work will be undertaken in the MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine with collaborative work at other sites across the science campus.

The post is full time and fixed term up to 31/03/2025, with the possibility of extension.