Senior Scientist - Sheffield, United Kingdom - Certara

Description

Certara accelerates medicines using proprietary biosimulation software, technology and services to transform traditional drug discovery and development. Its clients include more than 2,000 biopharmaceutical companies, academic institutions and regulatory agencies across 62 countries.

Simcyp is part of Certara, a company which combines sophisticated research and development informatics with the power of predictive science methodologies to span the drug development spectrum and offer pharma a previously unavailable 'end-to-end' solution in the quest for improving human health. The Simcyp team conducts cutting-edge research and provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases (implemented in its globally-recognized Simcyp Population-based Simulator) for a client base of major blue-chip pharmaceutical and biotechnology organizations. Simcyp focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the individual time-course and fate of drugs. We are on course to become the global industry standard, consequently, there is a continuous requirement for high quality people to join us, help in our expansion and share in our success.

We have an immediate opening for a Senior Scientist with a strong background in drug metabolism, transport, and pharmacokinetics. The candidate should be familiar with in vitro-in vivo extrapolation approaches and physiologically based pharmacokinetic modelling.

The successful candidate will undertake research projects related to further development of the compound and population libraries including the provision of model qualification documentation for use in regulatory submissions. This role requires a high level of attention to detail, good oral and written communication skills, and the need to respond quickly to queries received from clients. The successful applicant will be expected to disseminate the results of their research through publication of the results in scientific journals and presentations at scientific conferences.

Other duties include:
1) The provision of on-going customer support related to the use of the Simcyp Simulator.
2) Acting as a tutor and workshop lead on our and education and training programme.

The post does not include routine laboratory or clinical work.

The successful candidate will join an internationally recognized, multidisciplinary research team, providing opportunities for further development of knowledge and skills. We offer a unique and exciting mix of academic and commercial environments and encourage regular attendance at scientific meetings as part of our staff development programmes.

Essential

• PhD (or equivalent experience) in a relevant field with several years of practical experience.

• Knowledge of in vitro assays used in drug metabolism, transport, and pharmacokinetic studies and their application in IVIVE approaches.

• Knowledge of PK/PD properties of small and/or large molecules.

• Demonstrable communication skills, as evident by presentation at scientific meetings, and good interpersonal and organizational skills.

• Track record of publications in peer-reviewed literature.

Desirable

• Experience of managing other scientists.

• Good understanding of modelling and simulation principles of physiological and biological systems and parameter estimation techniques.

• Experience in prediction of drug-drug interactions.

• Awareness of R&D and/or regulatory process in pharmaceutical companies

• Some experience with R package would be beneficial.

• Experience in some aspects of QA would be beneficial.

• Experience of the Simcyp Simulator