- Vibrant and dynamic employment – we are a highly specialised, growth company operating in a critical sector of the economy – our future is strong and exciting
- Opportunities to develop your skills and yourself – our rapid growth brings greater opportunities for you to learn and grow faster
- A great team where we all support each other – enjoy your work – after all you spend about a third of your time here Key roles and responsibilities:
- Supporting crystallisation and isolation process development through laboratory experiments and materials characterisation assessment of starting materials, intermediates and APIs.
- Determining the appropriate combination of crystallisation and milling to deliver API with the desired particle size and physical properties.
- Performing DoE on crystallisation and milling processes to deliver the desired physical properties and impurity profiles.
- Monitoring reaction pathways and kinetics using appropriate PAT.
- Conduct analysis of samples for key physical properties including XRPD, optical microscopy, PSD and other relevant techniques.
- Assessment of polymorph landscape for final APIs and defining thermodynamically stable form.
- Assessment of solubility in a variety of media using appropriate methods.
- Supporting clients in helping to define final salt and polymorphic form based on a full materials characterisation assessment.
- Supporting preformulation assessment of final phases.
- Working within project teams working to tight deadlines.
- Able to step in and learn new techniques to support projects.
- Ability to solve complex scientific problems.
- Able to work effectively in a GMP laboratory.
- Present and communicate clearly and effectively with clients. Requirements:
- PhD in chemistry or relevant related subject with a technical focus on crystallisation for purity upgrade or particle engineering or PAT (additional industrial or academic experience preferred), or an MSC in chemistry with several years relevant industrial experience in crystallisation development or PAT.
- Knowledge of crystallisation methodologies relevant to drug substances.
- Familiarity with in-situ process analytical technologies for crystallisation process development (desired).
- Knowledge of data analytics and data visualisation tools.
- Knowledge of Design of Experiments (DoE) and related software (Desired).
- Significant expertise in troubleshooting and developing materials characterisation methods including XRPD, DSC, TGA, DVS, Microscopy and PSD. In-depth, hands-on expertise and up-to-date knowledge of other analytical methodologies.
- Experience using the following equipment would also be desired although not essential: Technobis Crystal 16, Crystalline or Crystal breeder, Mettler React IR, FBRM, BlazeMetrics, Easymax, other Spectroscopic PAT such as NIR or Raman
- Strong scientific record of accomplishment. Come and join a cutting-edge company that tackles the toughest scientific challenges for the world's leading pharmaceutical companies. At our company, we are passionate about advancing science and delivering solutions for our clients. We operate with ethics, integrity and professionalism. We work as a team and empower our employees to reach their full potential.Our Hoddesdon campus in Hertfordshire is a hub of innovation and excellence. It has over 5,000m2 of premier R&D space, including state-of-the-art GMP facilities for API, formulation and process chemistry. Our Analytical Chemistry team provides vital support to our chemistry functions and science partners with advanced analytical solutions.
- We offer a competitive salary and a progressive and comprehensive suite of employee benefits
- We offer state of the art working environment in our modern Hoddesdon site
- We offer the opportunity for growth and development and will support funding for relevant training and development programmes Why Should You Apply?
- This is an opportunity for you as a Chemistry professional to make a real impact in a highly scientific and regulated environment, demonstrate leadership, ambition and the desire to grow with the department.
- Build and shape your career in an environment that sets and commits to the highest standards of Chemistry.
- To be part of a team who support each other, embrace and solve technical challenges and put excellence at the heart of all that we do.
-
Senior Scientist, Crystallisation
1 week ago
Pharmaron Hoddesdon, Hertfordshire, United KingdomThis job is brought to you by Jobs/Redefined, the UK's leading over-50s age inclusive jobs board. · Job Introduction · Senior Scientist, Crystallisation · As a technical expert in Crystallisation Development, you'll have the chance to unleash your advanced knowledge in a varie ...
-
Brand Designer
2 weeks ago
Mind Gym London, United KingdomMindGym use the latest behavioural science to transform the performance of companies and the lives of people who work in them. But don't take our word for it. Since we started MindGym, we've partnered with over half the FTSE 100 and S&P 100, equipping them with an all-important h ...
-
Covid Vaccines
3 weeks ago
UK Health Security Agency London, United KingdomThe Vaccine Taskforce became the UKHSA Vaccine Unit on 1 October, continuing to ensure the best possible vaccines are available for the UK Population, whenever they are needed to fight what remains a fast evolving, deadly virus. Vaccines remain the key to the UK living with COVID ...
-
Performance Lead Remote
2 weeks ago
GlaxoSmithKline Ware, Hertfordshire, United KingdomThe Materials Science function is a team of experts within GSK's Global Supply Chain (GSC) MSAT (Manufacturing Science & Technology) division, which provides critical support, at pace, to GSK and third-party manufacturing sites for established products and new product introductio ...
-
Particle Science Lead
1 week ago
GlaxoSmithKline Ware, Hertfordshire, United KingdomSite Name: UK - Hertfordshire - Ware, Singapore - Jurong, UK - Hertfordshire - Stevenage · Posted Date: May · The Materials Science function is a team of experts within GSK's Global Supply Chain (GSC) MSAT (Manufacturing Science & Technology) division, which provides critical ...
-
Particle Science Lead
2 weeks ago
GlaxoSmithKline Hertfordshire, United KingdomSite Name: UK - Hertfordshire - Ware, Singapore - Jurong, UK - Hertfordshire - Stevenage · Posted Date: May · The Materials Science function is a team of experts within GSK's Global Supply Chain (GSC) MSAT (Manufacturing Science & Technology) division, which provides critical su ...
-
Associate Principle Scientist
1 week ago
Langton Howarth Cambridge, Cambridgeshire, United KingdomLocation: Site based in Pampisford, Cambridgeshire · This role is available as either full time Monday – Friday or part time (30 hours per week/4 days a week) · Our client is a leading integrated drug discovery CRO that has been setting the highest standards in drug discovery, ...
-
Senior Scientist, Materials Science
3 days ago
GlaxoSmithKline Stevenage, United Kingdom Full timeSite Name: UK - Hertfordshire - Stevenage · Posted Date: Mar · Materials Science provides holistic understanding of how structure influences particle and powder properties to design a crystallisation process to optimise drug product manufacture and performance. As projects advan ...
Senior Scientist, Crystallisation - Hoddesdon, United Kingdom - Pharmaron
