PhD Studentship: Development and Application of Enabling Methods for Drug Discovery - Birmingham, United Kingdom - University of Birmingham

University of Birmingham Birmingham, United Kingdom

3 weeks ago

Full time, Fixed-Term/Contract

Description

Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with molecular and temporal resolution. Addressing this challenge will illuminate our understanding of disease development e.g. cell signalling in cancer or aggregation in amyloid disease and provide starting points for drug-discovery. However, methods to interrogate and manipulate PPIs are not well established. Moreover, intrinsically disordered regions – segments of protein with no fixed structure – that undergo disorder-to-order transitions upon formation of the PPI, compound this challenge.

A number of approaches to modulation of PPIs including competitive inhibition, stabilization and allosteric inhibition can be envisioned. Informed by structural and mechanistic understanding of the interactions between IDRs and their client proteins,[1] our group has developed a number of enabling methods that include computational methods[2] constrained peptides,[1] secondary structure mimetics[3] and covalent inhibitors.[4] In tandem we are applying novel fragment discovery methods[5] and developing tag-transfer cross-linking[6] to map ligand binding sites. In this PhD project the student will extend and apply these methods to focussed PPI modulator projects. Current targets include: BH3/BCl-2 family,[1] HIF-1α/p300,[7] interactions of proteins,[8] (all oncology), and GKAP/SHANK-PDZ (synaptic function).[3]

A range of methods appropriate to the target will be employed including: computational prediction, peptide chemistry, novel fragment-screening technologies, development of new covalent warheads, biophysics and structural-molecular biology. This will allow the design, synthesis and testing of candidate PPI modulators to discover selective and cell-permeable modulator of the target PPI and ultimately chemical probes.[9] You will join a vibrant, diverse and group of researchers to gain skills and knowledge in chemical biology in its broadest sense, and participate in our wider collaborative research.

The project will be supervised by Prof Andy Wilson ).

Funding notes:

We offer a fully-funded programme of integrated research and skills training with cross-disciplinary supervision. This studentship includes stipend and tuition fees paid at the UKRI level. Support for conference attendance and research materials will be available.

References:

J. Miles, D. Yeo, P. Rowell, S. Rodriguez-Marin, C. Pask, S. Warriner, T. Edwards and A. Wilson, Chem. Sci., 2016, 7,
A. Ibarra, G. Bartlett, Z. Hegedüs, S. Dutt, F. Hobor, K. Horner, K. Hetherington, K. Spence, A. Nelson, T. Edwards, D. Woolfson, R. Sessions and A. Wilson, ACS Chem. Biol., 2019, 14,
S. Celis, F. Hobor, T. James, G. Bartlett, A. Ibarra, D. Shoemark, Z. Hegedüs, K. Hetherington, D. Woolfson, R. Sessions, T. Edwards, D. Andrews, A. Nelson and A. Wilson, Chem. Sci., 2021, 12,
T. Ueda, T. Tamura, M. Kawano, K. Shiono, F. Hobor, A. Wilson and I. Hamachi, J. Am. Chem. Soc., 2021, 143,
E. Cawood, N. Guthertz, J. Ebo, T. Karamanos, S. Radford and A. Wilson, J. Am. Chem. Soc., 2020, 142,
J. Horne, M. Walko, A. Calabrese, M. Levenstein, D. Brockwell, N. Kapur, A. Wilson and S. Radford, Angew. Chem. Int. Ed., 2018, 57,
F. Hóbor, Z. Hegedüs, A. Ibarra, V. Petrovicz, G. Bartlett, R. Sessions, A. Wilson and T. Edwards, RSC. Chem. Biol., 2022, 3,
S. Srdanovic, M. Wolter, C. Trinh, C. Ottmann, S. Warriner and A. Wilson, FEBS J., 2022,
J. Blagg and P. Workman, Cancer Cell, 2017, 32, 9-25.

To apply please email your cv via the above 'Apply' button.

UKRI level

Band 4 Clinical Research Assistant

3 weeks ago

University Hospitals Birmingham NHS Foundation Trust Birmingham, United Kingdom

The role requires an individual with excellent organisational and communication skills, effective time management, and ability to work with minimum supervision. You must be able to use a variety of databases and computerized systems to extract, enter and report data. · You should ...
Band 4 Clinical Research Assistant

3 weeks ago

University Hospitals Birmingham Birmingham, United Kingdom

**Job summary**: · The role requires an individual with excellent organisational and communication skills, effective time management, and ability to work with minimum supervision. You must be able to use a variety of databases and computerized systems to extract, enter and report ...
Research Fellow

1 week ago

University of Birmingham Birmingham, United Kingdom

**Position Details** · Institute of Inflammation and Ageing, College of Medical and Dental Sciences · Location: University of Birmingham, Edgbaston, Birmingham UK · Full time starting salary is normally in the range £33,348 to £43,155 with potential progression once in post to £4 ...
Nabis - Data Visualisation and Research Officer

2 weeks ago

West Midlands Police Birmingham, United Kingdom

**Job Title**:NABIS Data Visualisation and Research Officer · **Type**:Police Staff - Grade 6 · **Salary**:£32,409 - £37,953 · **Employee Type**:Permanent · **Location**:Central Birmingham (with potential travel around the UK) · **Closing Date**:Tuesday 5th September 2023 · **Nat ...
Team Leader, in Vivo Pharmacology, Dr O. Rossanese

3 weeks ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Competitive Starting Salary** · **Hours per week**: 35 hours per week (Full Time) · **Closing Date**:31st July 2023 · **Job Details**: · Under the leadership of Dr Olivia Rossanese, the ICR is now seeking a leading cancer biologist with a track record of ...
Scientific Officer/ Higher Scientific Officer- Drug

3 weeks ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Duration of Contract**: 2 years · **Hours per week**: 35 hours per week (Full Time) · **Closing Date**:3rd March 2024** · **Job Details**: · We are seeking to appoint a Scientific Officer/ Higher Scientific Officer (dependant on experience) to join the Dr ...
Clinical Trial Assistant

2 weeks ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Salary**: £20,166 per annum (pro rata) · **Duration of Contract**: Fixed Term for 6 months · **Hours per week**: 20 hours per week (Part Time). · **Location**: Sutton. · **Closing Date**: 4th December 2023 · **Job Details**: · **Key Information** · **Key ...
Clinical Trial Assistant

2 weeks ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Salary**: £23,997 · **Duration of Contract**: Fixed Term for 12 months · **Hours per week**:35 hours per week (Full Time). · **Location**: Sutton. This role is not eligible for hybrid working. · **Closing Date**: 29th April 2024 · **Potential Interview Da ...
Biological Specimen Coordinator

1 week ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Salary**: · **Duration of Contract**: Maternity cover up to 12 months · **Hours per week***: 35 hours per week (Full Time) · **Closing Date***:21st November 2023 · **Job Details**: · Under the leadership of Professor Johann de Bono, we are seeking to appo ...
Licensed Animal Technician

1 week ago

S3 Science Sutton, United Kingdom

Licensed animal Technician · £ £32000 · We are proud to be working with our client, one of the world's most influential organisations that specialise in Cancer studies, on the hunt for a Licensed Animal Technician to join their team. Our client holds outstanding achievements in d ...
Higher Scientific Officer

1 day ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Duration of Contract**: Fixed Term for 2 years in the first instance · **Hours per week***: 35 hours per week (Full Time) · **Closing Date***:17th December 2023 · **Job Details**: · The In Silico Informatics Team is a cross disciplinary team consisting of ...
Staff Scientist

1 day ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Duration of contract**: · ***Permanent · **Hours per week**:35 hours per week (Full Time) · **Location**: Sutton. This role is site-based · **Closing Date***: 29 January 2023 · **Job Details**: · Under the leadership of Dr Olivia Rossanese, we are seeking ...
Staff Scientist

1 day ago

The Institute of Cancer Research Sutton, United Kingdom

**Location**: · - Sutton (Greater London)**Department**: · - Cancer Therapeutics**Salary Details**: · - Salary Range: £50000 to £70000 per annum**Contract**: · - Permanent**Advertising End Date**: · - 29 Jan 2023- Key Information*** · **Duration of contract**: · ***Permanent**Hou ...
Staff Scientist- Biology, Centre of Protein

7 hours ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Hours per week**: 35 hours per week · **Closing Date**: 1st June 2023 · **Job Details**: · Under the leadership of Olivia Rossanese, we are seeking to appoint a Staff Scientist to join the Centre for Protein Degradation, in the Division of Cancer Therapeu ...
Clinical Trial Assistant

5 days ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Salary**: £20,166 · **Duration of Contract**: Fixed Term for 12 months · **Hours per week**: 35 hours per week (Full Time). · **Location***:Sutton. This role is not eligible for hybrid working. · **Job Details**: · **Key Requirements** · There are several ...
Clinical Sample Processor

1 day ago

The Institute of Cancer Research Sutton, United Kingdom Part time

**Key Information**: · **Duration of Contract**: Fixed Term for 12 months · **Hours per week**: Part Time 5-20 hours per week (Monday to Friday 5pm to 3am) · **Closing Date**: 29th March 2024 · **Job Details**: · We are seeking to appoint a Clinical Sample Processor will be respo ...
Senior Staff Scientist

4 days ago

The Institute of Cancer Research Sutton, United Kingdom

**Key Information**: · **Duration of Contract**: Fixed term contract for 2 years · **Hours per week***: 35 hours per week (Full Time) · **Location**: Sutton. This role is site-based · **Closing Date**: 15 January 2023 · **Job Details**: · We are seeking to appoint a Senior Staff ...
Senior Administrative Assistant

3 weeks ago

Pfizer Hurley, United Kingdom

Job Description: Senior Administrative Assistant · Role Summary · Must be able to perform duties with a high level of professionalism and mínimal supervision. Must have the ability to prioritise and work independently yet be a team player. Handles multiple demands and priorities ...
Reporting Officer

3 weeks ago

Eurofins UK Forensic Services Tamworth, United Kingdom

Company Description · Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to th ...
Research Scientist/study Director

1 week ago

hr-inspire Ltd Osgathorpe, United Kingdom

**Job Title: Study Director/ Research Scientist** · **Location**: Osgathorpe, Loughborough, Leicestershire LE12 9TE · **Hours**: Full Time · **Contract**: Permanent · **Salary**: Competitive · CrownBio is a Cutting Edge Translational Technology Company Making Precision Medicine a ...