Senior Investigator Scientist LMS 2396 - London, United Kingdom - Medical Research Council

Medical Research Council London, United Kingdom

Found in: Talent UK C2 - 3 days ago

Description

View Vacancy -- Senior Investigator Scientist LMS 2396

Open Date 15/04/2024, 00:00 /*generated inline style */ Close Date /*generated inline style */ 05/05/2024, 23:55 /*generated inline style */ Research Institute 1 MRC Laboratory of Medical Sciences /*generated inline style */ Research Institute / Unit Information 1

where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation, the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12).

The LMS aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment. Part of achieving this, is to recruit new talent and support postdoctoral scientists to become world leaders in their area of science.

/*generated inline style */ UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

/*generated inline style */ Band 1 MRC - 3 /*generated inline style */ Location 1 London /*generated inline style */ Salary 1 £48,802 - £52, 172 plus London Allowances (£3,913 & £1,472) per annum /*generated inline style */ Contract Type 1 Fixed Term /*generated inline style */ Job Type 1 Science /*generated inline style */ Full Time / Part Time 1 Full Time /*generated inline style */ Contract Length 1 4 years /*generated inline style */ Job Description 1

Overall Purpose:

The LMS, under the Directorship of Professor Wiebke Arlt, is one of three UK institutes which are core-funded by the MRC. Partnered with Imperial College London on its Hammersmith Hospital Campus, it comprises around 35 research groups carrying out biomedical research which addresses the fundamental mechanisms responsible for human health and disease, using state-of-the-art core facilities. Our research focuses on metabolism and genetics with a particular spotlight on the impact of sex differences, ageing and environmental factors, and our approach is transdisciplinary team science.

The Functional Gene Control Group:

Headed by PI Dr Mikhail Spivakov, the LMS is appointing a Senior Investigator Scientist with an established track record of wet-lab research in gene regulation to perform semi-independent research, lead on the methodological developments in the lab, and support and co-supervise junior lab members.

The main key responsibilities of the role include:

Lead research on the mechanisms of enhancer function and enhancer-promoter communication, and/or on developing novel techniques relevant for this research area, with a high degree of independence

Establish, maintain and troubleshoot experimental techniques for studying the regulatory genome, such as epigenomics, 3D genomics and single-cell multiomics assays, as well as CRISPRi/a perturbation screens

Provide effective supervision to undergraduate and masters student(s) hosted in the lab working on relevant projects

Train, co-supervise and assist lab members with their projects, particularly those involving challenging experimental techniques

Lead on lab management duties

Participate and, where required, project-manage collaborations to expand the scope of the lab's research

Write-up and publish research results, assist in preparing collaborative work for publication

Present at scientific meetings

Contribute to writing bids for research grants

Balance independent work with team science, both within the lab, other teams in the institute and beyond

Take an active part in the academic activities of the group including group meetings, group journal clubs, training and organisational aspects

Take an active part in the academic activities of the LMS, including seminar presentations

Support the LMS's values of Equality, Diversity and Inclusion

/*generated inline style */ Person Specification 1

Education / Qualifications / Training required (will be assessed from application form):

Essential:

A PhD supported by post-doctoral experience in either industry or academia in the field of gene regulation, 3D genomics and/or developmental epigenetics

Previous work experience ( will be assessed from application form and at interview):

Essential:

Experience of gene regulation, 3D genomics and/or developmental epigenetics demonstrated by excellent (joint-)lead author publications. Note: Preprints will be considered, but at least one peer-reviewed publication is expected

Experience of establishing and troubleshooting techniques in the lab

A record of scientific originality and creativity, demonstrated through publications

Experience of mammalian cell culture

Experience of supporting and supervising students and junior researchers

Desirable:

Experience as a senior, semi-independent researcher in academia or industry, such as a senior postdoc, career development fellow or team leader

Experience of lab management

Knowledge and experience (will be assessed from application form and at interview) :

Essential:

Excellent technical skills in transcriptomics, epigenomics and 3D genomics

Experience in single-cell genomics assays

A good understanding of NGS data analysis

Desirable:

A working knowledge of CRISPRi/a perturbation screens

A working knowledge of stem cell culture or primary blood cell isolation

Experience in single-cell multiomics assays

Personal skills / Behaviours / Qualities (will be assessed at the interview) :

Essential:

Good leadership skills that inspire and motivate others to support high quality outputs

Excellent communication skills to convey complex information clearly to wide audiences

Ability to organise and prioritise workload, and to delegate appropriate tasks to team members ensuring deadlines are met

A high level of motivation to learn new concepts and acquire new skills in biology and computing, and to seek novel and creative solutions to scientific problems

Committment to maintaining confidentiality of data at all times

A flexible approach to working, with the ability to sometimes work outside of core hours (including weekends) if the requirements of the project demand

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