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Head of Protein Engineering
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Protein Engineer
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Hlx Life Sciences Oxfordshire, United KingdomJob Description We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. This role is full-time and requires on-site presence for five days a week. · Test, screen and produce soluble TCR-based therapeutics for clinical d ...
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Protein Biochemistry and Engineering
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Molecular Biologists/biochemists
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University of Oxford Oxford, United KingdomWe are seeking a full-time Senior Research Associate to join an interdisciplinary research team developing new stimulus-responsive techniques for ultrasound-mediated immune-modulation at the Institute of Biomedical Engineering (Botnar Research Centre, Headington). The full-time p ...
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Postdoctoral Research Assistant
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Scientific Internships
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Molecular Biologist
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Research Associate
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Qc Stability Scientist
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Biologics Production Scientist
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Cell Biologist
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Bioinformatician
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Hlx Life Sciences Oxfordshire, United KingdomWe are working in partnership with a start-up biotech firm, supporting them in the growth of their business and they are seeking a Bioinformatician to join their team. · In this role you will be responsible for bioinformatic analysis of public and internal bulk and single cell R ...
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Research Scientist
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Workday Oxford, United KingdomFor Current Gilead Employees and Contractors: · Please log onto your Internal Career Site to apply for this job. · At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of incl ...
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Bioinformatician
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Hlx Life Sciences Oxfordshire, United KingdomWe are working in partnership with a start-up biotech firm, supporting them in the growth of their business and they are seeking a Bioinformatician to join their team. Role SummaryIn this role you will be responsible for bioinformatic analysis of public and internal bulk and sing ...
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Scientist - Chemical
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Researcher - Network
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E.C. Ellis Oxford, Oxfordshire, United KingdomAre you an expert in machine learning and artificial intelligence? You will be apply cutting-edge machine learning techniques, solving complex problems in the medical/pharmaceutical research field. · Apply machine learning to solve complex problems · Collaborate with a variety ...
Protein Engineer - Oxfordshire, United Kingdom - Hlx Life Sciences
Description
We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. They're actively seeking Protein Engineers with Phage Display expertise across varying levels of seniority to join their team.This role is full-time and requires on-site presence for five days a week.
Role SummaryIn this role you will be a core part of the Protein Engineering team, working collaboratively with other protein engineers and biochemists to develop soluble high affinity bispecific TCR molecules suitable for later stage clinical development.
Key DeliverablesTest, screen and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches.
Will include:
(a) develop and undertake established and novel strategies to affinity mature candidate soluble TCRs; (b) design and construction of affinity maturation TCR libraries (c) Screening of affinity maturation libraries outputs for affinity and cross reactivity; (d) DNA recombinant subcloning (e) sequence analyses of the library outputs.
Collaboratively with the Biology and CMC teams to guide optimisation and development of soluble TCRs.
Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
Work to your department, project team and the company leadership team.
Collaboratively with the other teams to guide optimisation and development of soluble TCRs.
Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively.
Scientific findings and summary conclusions to your department, project team and the company leadership team.
Drive innovation and continuous improvement within the Protein Engineering team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process;Experience & Qualifications RequiredProvide oversight of specific elements within a project or projects and supervise other scientists.
A PhD in a relevant biological subject alongside some postdoctoral experience and/or experience in the biotech/pharma industry.(Desired but not essential) Experience line managing/supervising other scientists.(Desired but not essential) Experience working in a matrix environment.
Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules using molecular evolution approach (phage display, yeast display etc.Strong proven expertise in molecular biology and protein engineering techniques, including rational design, phage display, library construction, affinity maturation approaches, site directed mutagenesis, cloning.
Experience in screening affinity maturation outputs and candidate molecules through techniques such as ELISA, DNA sequence analyses etc.(Desired but not essential) Experience in purifying and refolding proteins.(Desired but not essential) Experience in analyses of protein affinity and cross-reactivity using SPR/Biacore.
Working proactively with the team to develop effective strategies prioritised to the needs of the Protein Engineering group; collaborating effectively with other functions.
Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.Strong communication skills with the confidence and judgement to challenge appropriately.
Demonstrable problem- solving ability, creative thinking and be pro-active in driving the project forwards;
