KOODAC Team Chemical Biologist - Dundee, United Kingdom - University of Dundee

Description

We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with experience in compound screening and assay development to join the group of Professor Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic, multi-disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer Grand Challenges, within KOODAC ). KOODAC's mission is to discover and develop small-moleculedrugsthatdegradekeyoncogenicdriversofsolidtumoursinchildren , as a novel therapeutic paradigm to treat pediatric cancers. The team will develop two types of degraders – proteolysis targeting chimeras (PROTACs) and molecular glue degraders. Both classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce target's ubiquitination and degradation, leading to cell death. The team will focus on developing degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive rhabdomyosarcoma, respectively, in children.

The successful candidate will be expected to drive the screening and identification of hit molecules for rational design and development into novel small-molecule degraders. You will pioneer the design, implementation, and execution of high-throughput approaches to automated plate-based compounds synthesis and "direct-to-biology" screening across the project targets, and to contribute to screening assay design and optimization for hit identification across the programme. You will work closely with the Senior Lead Scientist and the other PDRAs within the team in the Ciulli Lab, as well as scientists at our collaborating partners of the KOODAC Team to develop a platform for the discovery, characterisation and development of degraders for the oncoprotei ns of interest.

Candidate Requirements:

• A Ph.D. in chemical biology, medicinal chemistry, pharmaceutical sciences, or a related discipline
• Expertise in compound design, synthesis and screening/characterization.
• Outstanding academic and/or industrial track record.
• Excellent interpersonal, communication and presentation skills.
• Capable of working in a diverse team, but able to plan and work independently.
• Exceptional time management, organisational and self-motivational skills.
• An open and collaborative approach to science.

Preferred skills:

• Experience in automated synthesis / high-throughput chemistry and/or high-throughput screening are strongly desired.
• Experience with studying of PROTACs and/or molecular glue degraders.
• Experience with mass-spectrometry proteomics and chemoproteomics approaches would be an advantage.

The position is available immediately and for a fixed-term of 5 years. For further information about this role contact Professor Alessio Ciulli at To find out more about Group please visit the group's Website.