Computational Postdoctoral Fellow - Hinxton, United Kingdom - Wellcome Sanger Institute

Description

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

The Opportunity:

The Cellular Genetics Programme is seeking a Postdoctoral Fellow to work on iPSC derived organoid datasets in the Haniffa Group. The Programme is focused on cell-atlasing and aims to map tissues and organoids by combining single-cell transcriptomics, spatial genomics and computational methodologies to build full-transcriptome three-dimensional (3D) models of cells in their tissue context.

About the Team:

Muzlifah Haniffa is a dermatologist pioneering the applications of single cell genomics technologies to understand human development, tissue homeostasis, immunity and disease pathogenesis. A major research goal of her laboratory is to decode the development and functional maturation of the human immune system and whole embryo development. The Haniffa Group's research within the Cellular Genetics Programme applies disruptive cutting-edge single cell and spatial genomics techniques to study human development and adult healthy and diseased tissues. The group is a diverse mixture of wet and dry lab researchers and clinicians and collaborates closely with leading teams in single cell and spatial biology including Sarah Teichmann, Fabian Theis and Mohammad Lotfollahi.

About the Role:

You will analyse large single-cell genomics including spatial genomics datasets relating to organoid research to deliver key insights. You will be closely interacting with the wet lab team, driving organoid development by generating large-scale atlases, identifying key regulatory mechanisms, and perturbing them in silico thereby actively promoting hypothesis testing and translational research. You will work collaboratively with other researchers including bioinformaticians in the Haniffa group, Cellular Genetics programme including the IT team, EBI and international collaborators.

About You:

You understand key concepts in genomics, data processing and high-throughput data analysis. You will ideally have experience in the management and analysis of very large data sets, using or developing statistical/machine-learning methods for the analysis of large-scale data sets. You have the clarity to understand complex computational concepts, apply them to address proposed biological questions and present the results to diverse audience.

Knowledge, skills and experience required:

Technical Skills:

• PhD in relevant subject area, or on track to be awarded your PhD within 6 months of starting the role
• Proven ability to deliver research projects
• A track record of demonstrating research excellence and expertise in your area of research
• Knowledge, skills and experience as appropriate to research area e.g.

o Ability to analyse and interpret data with strong quantitative/computational skills

o Programming and bioinformatics skills

Competencies and Behavioural Skills:

• Proven ability to develop and maintain effective working relationships with wide range of persons of differing level, abilities and knowledge
• Foster an inclusive culture where all can thrive and diversity is celebrated
• Team player with the ability to work with others in a collegiate and collaborative environment
• Ability to effectively communicate ideas and results and present orally to groups
• Commitment to personal development and updating of knowledge and skills
• Ability to priortise, multi-task and work independently
• Detailed orientated, strong organizational and problem-solving skills

Additional Information

Application: please apply with your CV and cover letter, detailing how you meet the criteria for the role.

Closing date: 7th June 2024

Salary: £38, ,156 (dependent on skills and experience)

Contract: 3 years

Hybrid Working at Wellcome Sanger:

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion:

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits:

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines.