Associate Director/director, Dmpk - Cambridge, United Kingdom - Bicycle Therapeutics

Bicycle Therapeutics

Verified Company

Cambridge, United Kingdom

1 week ago

Posted by:

Tom O´Connor

beBee Recruiter

Description

Company Description
Bicycle Therapeutics (

NASDAQ:
BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines.

Our pipeline includes Bicycle Toxin Conjugates as well as fully synthetic Bicycle systemic immune cell agonists and Bicycle tumor-targeted immune cell agonists (Bicycle TICAs) focused on oncology indications with high unmet medical need.

Bicycle is headquartered in Cambridge, UK, and our US operations run out of Lexington, MA.

Culture is key and all Bicycle employees actively embrace and role model our company values:

We are
Adventurous. We believe it's the way to deliver extraordinary results for our patients.
We are
Dedicated to our Mission. You can't change the world if you don't have determination.
We are
One Team. We only succeed when we work together.

Job Description:

KEY RESPONSIBILITIES

Design and implement the appropriate DMPK strategy including data interpretation and presentation at multifunctional project teams.
Perform DMPK activities including interactions with external CRO's and internal project stakeholders.
Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion (DME).
Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK (DME and PK) properties.
Work closely with invivo pharmacology, toxicology and/or clinical pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (PK/PD) relationships and enable human efficacious dose projection.

Qualifications:

Relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
Broad and indepth understanding of DMPK science with additional knowledge of related disciplines.
Experience working on DMPK drug discovery and/or development projects as a DMPK representative with a track record of problem solving and successful delivery across drug discovery.
Handson experience in IVIVC, IVIVE, in silico, PK, PK/PD, and/or physiologically based pharmacokinetics (PBPK) analysis and modeling would be preferred.
Previous experience working on peptidesmacrocycles would be an advantage.
Ability to adapt your working style to suit different cultures and partner expectations in both remote and officebased environment.
Excellent organization and communication skills, both written and oral, with the ability to influence.

Additional Information

Stateoftheart campus environment with on campus restaurant and Montessori nursery
Flexible working environment
Competitive reward including annual company bonus
Employee recognition schemes
28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
Employer contribution to pension (employee does not have to contribute)
Life assurance cover 4x basic salary
Private Medical Insurance, including optical and dental cover
Enhanced parental leave policies
Group income protection
Employee assistance program
Health Cash Plan
Access to company subsidized gym membership
Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status._