Molecular Biologist - Didcot, United Kingdom - Medical Research Council

Medical Research Council Didcot, United Kingdom

Found in: Talent UK C2 - 3 days ago

Description

View Vacancy -- Molecular Biologist - MLC 2394

Open Date 15/04/2024, 00:00 /*generated inline style */ Close Date /*generated inline style */ 19/05/2024, 23:55 /*generated inline style */ Research Institute 1 MRC Mary Lyon Centre /*generated inline style */ Research Institute / Unit Information 1 The (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research. As the hub of the new National Mouse Genetics Network, the specialist facilities and capabilities of the MLC support a number of research groups across the UK to accelerate our understanding of human diseases, such as cancer, developmental disorders and neurodegeneration. /*generated inline style */ UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

/*generated inline style */ Band 1 MRC - 4 /*generated inline style */ Location 1 Harwell Campus, Oxfordshire /*generated inline style */ Salary 1 £39,375–£43,962 per annum, dependent on skills and experience /*generated inline style */ Contract Type 1 Permanent /*generated inline style */ Job Type 1 Technical & Scientific Professionals /*generated inline style */ Full Time / Part Time 1 Full Time /*generated inline style */ Job Description 1

Overall Purpose:

The Mary Lyon Centre at the Medical Research Council Harwell (MLC) is recruiting a Molecular Biologist to work as part of a genome engineering team and on a collaborative technology development programme in Genome Editing and Engineering. The successful candidate will work within the Molecular and Cellular Biology (MCB) group and in close collaboration with the Genotyping core facility. Their activity will span genome editing and gene targeting of the mouse genome at scale and functional validation of engineered alleles.

The available post is based within established laboratories that have significant existing expertise in genome engineering in the generation and quality control of engineered mouse alleles. The successful candidate will work as part of a team and will be responsible for the design and validation of genome-engineered mouse models. They will advise genome editing service users. They will design genetically altered alleles, editing reagents and genotyping assays. They will work collaboratively with the MCB team and with the MLC groups responsible for mouse production, breeding and embryo manipulation. They will review the data for validation of new alleles. The post-holder will collaborate with other senior members in the group to analyse production data, refine lab processes and present findings in publications. They will work as part of a team and, once familiar with the service's work, participate in the team's programme of technology development.

An understanding of gene structure and expertise in standard molecular biology techniques (PCR, sequencing) are required. Previous experience in the analysis of Sanger sequencing data is desirable. Specialist training in genome engineering can be provided.

Main Duties/Key Responsibilities:

Design and validation of genome-edited mouse models

Liaison with Genome Editing and Engineering Service users

Coordination of molecular biology tasks in the MCB team and collaboration with other teams in the Mary Lyon Centre

Review of data and production processes as part of a team

Design of new engineered alleles

Dissemination of knowledge in genome engineering, taking part in writing publications and teaching at specialist workshops

Working Relationships:

Design and validate genome-engineered alleles for the generation of models, working as part of a team with the other Molecular and Cellular Biology (MCB) team members, including direct reports, and reporting to the Head of MCB

Work with scientists in the various research groups, to help design alleles for new mouse models

Interface with the senior team of the Mary Lyon Centre, including the Director and Heads of Departments, to deliver key programmes and services

Additional Information:

Some flexible working patterns and paid weekend work may be required at the discretion of the supervisor.

/*generated inline style */ Person Specification 1

Education/Qualifications/Training Required:

Essential:

PhD in Biological Sciences, or equivalent, involving the use of molecular biology

Understanding of gene structure/function

Previous Work Experience Required:

Essential:

Use or generation of genetically altered cell lines or animals

Extensive use of PCR-based techniques

Previous experience in genotyping

Desirable:

Experience of Sanger sequencing or digital PCR

Evidence of quality- and customer-focused work

Knowledge and Experience:

Essential:

Experience of several of the following Molecular and Cellular Biology techniques: gene targeting, genome editing, PCR, Sanger sequencing analysis, ddPCR, in vitro transcription

Computer literacy is essential for the recording and communication of results

Desirable:

Working and adhering to standard operating procedures and experience of process analysis and refinement

Experience in service provision

Personal skills/Behaviours/Qualities:

Essential:

Organised and hard-working, with a strong eye for detail

Able to work well as part of a team and develop leadership skills

Desirable:

Able to communicate clearly and concisely with a variety of scientists at all levels (from principal investigator to research assistants and animal technicians)

/*generated inline style */

Molecular Biologist

Found in: beBee S2 UK - 5 days ago

MRC - Mary Lyon Centre Harwell, United Kingdom Full time, Permanent

You will be based within established laboratories with significant genome engineering in the generation and quality control of engineered mouse alleles. You will work as part of a team on a collaborative technology development programme in Genome Editing and Engineering and be re ...
Senior Molecular Biologist

Found in: Talent UK C2 - 3 days ago

Medical Research Council Didcot, United Kingdom

View Vacancy -- Senior Molecular Biologist - MLC 2389 · Open Date 11/04/2024, 00:00 /*generated inline style */ Close Date /*generated inline style */ 19/05/2024, 23:55 /*generated inline style */ Research Institute 1 MRC Mary Lyon Centre /*generated inline style */ Research In ...
Molecular Biologist

Found in: Talent UK A C2 - 2 days ago

SRG Bracknell, United Kingdom

· Job title: Molecular biologist · Location: Bracknell, Berkshire. · Contract: 12- month FTC. · Pay rate: £19.56 p/h. · SRG are looking for an experienced molecular and plant biologist to work with a global agrochemical company based in Bracknell, Berkshire. As a molecular bio ...
Molecular Biologist

Found in: Jooble UK O C2 - 4 days ago

NES Fircroft Ltd Bracknell, Berkshire, United Kingdom

This is a unique chance for a biologist who specialises in invertebrates to apply their expertise to propose, design and execute experiments to improve our understanding of these novel pesticides. If successful, you will be part of a team using automated analysis of behaviour to ...
Senior Research Scientist II

Found in: Adzuna UK C2 - 6 days ago

Pharmiweb Abingdon, United Kingdom

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. ...
Senior Research Scientist I

Found in: Jooble UK O C2 - 6 days ago

Immunocore Abingdon, Oxfordshire, United Kingdom

IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D a ...
Senior Research Scientist I

Found in: Jooble UK O C2 - 6 days ago

Immunocore Abingdon, Oxfordshire, United Kingdom

Senior Research Scientist II – Oncology Research, Functional Pharmacology · Vacancy Name Senior Research Scientist II – Oncology Research, Functional Pharmacology · Employment Type Full Time · IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose ...
Senior Research Scientist, Computational Drug Design

Found in: Talent UK C2 - 3 days ago

Vertex Oxford, United Kingdom Full time

Job Description · General Summary: · We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Oxford. This individual will be responsible for contributing to both hit/lead identification and optimization programs using ...
Senior Research Scientist, Computational Drug Design

Found in: Jooble UK O C2 - 1 day ago

Vertex Pharmaceuticals Oxford, Oxfordshire, United Kingdom

Senior Research Scientist, Computational Drug Design page is loaded · Senior Research Scientist, Computational Drug Design · Apply locations Oxford, United Kingdom time type Full time posted on Posted 2 Days Ago job requisition id REQ-21907 Job Description · General Summary: ...
Research Assistant

Found in: beBee S2 UK - 4 days ago

University of Oxford Oxford, United Kingdom Full time, Fixed-Term/Contract

We are seeking an enthusiastic Research Assistant to work within a vibrant research team headed by Professor David Hodson at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) on studies related to type 1 diabetes ). · The postholder will contribute to a Steve Mo ...
Senior Scientist

Found in: Appcast UK C C2 - 10 hours ago

Cranleigh STEM, Sustainability & SHEQ Recruitment Reading, Berkshire, United Kingdom

We have an exciting opportunity for an experienced scientist to join a growing therapeutics organisation. You will contribute to cutting-edge research in the development of therapeutics for veterinary diseases. The role requires expertise in in vitro assay development, molecular ...
Research Scientist

Found in: Jooble UK O C2 - 4 days ago

Careeraddict Bracknell, Berkshire, United Kingdom

Molecular Biologist - Research Scientist · One of our global clients is looking for a Molecular Biologist Scientist to join their R&D Team on a contract basis. · The role is initially for one year contract. · Resolves routine issues with minimal senior staff or supervisory gui ...
Senior/Principal Scientist

Found in: Ziprecruiter UK C2 - 2 days ago

Cranleigh STEM, Sustainability & SHEQ Recruitment Reading, United Kingdom

Job Description · We have an exciting opportunity for an experienced scientist to join a growing therapeutics organisation. You will contribute to cutting-edge research in the development of therapeutics for veterinary diseases. The role requires expertise in in vitro assay devel ...
Research Scientist

Found in: Jooble UK O C2 - 4 days ago

ROYAL SOCIETY OF CHEMISTRY Bracknell, Berkshire, United Kingdom

Contract: 12- month FTC. · As a molecular biologist, you'd be working at a world class research and development facility, in a team of passionate scientists, planning and carrying out studies in plant to plant and insect biology and symptomology. · This role would suit a PhD gr ...
Senior/Principal Scientist

Found in: Jooble UK O L C2 - 3 days ago

Cranleigh STEM, Sustainability & SHEQ Recruitment Reading, Berkshire, United Kingdom

We have an exciting opportunity for an experienced scientist to join a growing therapeutics organisation. You will contribute to cutting-edge research in the development of therapeutics for veterinary diseases. The role requires expertise in in vitro assay development, molecular ...