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Research Associate/Senior Research Associate in Immunoassay Development
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Research Associate/Senior Research Associate in Immunoassay Development
Found in: Talent UK C2 - 2 hours ago
Newcastle University Newcastle upon Tyne, United Kingdom Full timeSalary: · Research Associate: £33,966 - £44,263 per annum · Senior Research Associate: £45,585 - £54,395 per annum · Newcastle University is a great place to work, with excellent . We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a ...
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Senior Research Software Engineer
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Senior R&D Director ASR
Found in: Jooble UK O L C2 - 4 days ago
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Research Associate Biostatistician
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Research Associate Biostatistician
Found in: Talent UK C2 - 2 hours ago
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Technical Specialist
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Technical Specialist
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Research Associate/Senior Research Associate in Immunoassay Development
Found in: beBee S2 UK - 1 day ago
Newcastle University Newcastle upon Tyne, United Kingdom Full time, Fixed-Term/ContractCompany description: · We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fu ...
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Senior Research Software Engineer
Found in: Talent UK C2 - 6 days ago
Newcastle University Newcastle upon Tyne, United Kingdom Full timeSenior Research Software Engineer · Requisition ID: 26873 · Location: Newcastle, GB · Contract Type: Fixed Term · Working Pattern: Full Time · Posted Date: 2 Apr 2024 · Salary: £45,585 to £48,350 with progression to £54,395 per annum · Newcastle University is a great place to wor ...
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Senior Research Software Engineer
Found in: Talent UK C2 - 6 days ago
Newcastle University Newcastle upon Tyne, United KingdomSalary: £45,585 to £48,350 with progression to £54,395 per annum · Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives ...
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Newcastle University Newcastle upon Tyne, United Kingdom Full time, Fixed-Term/ContractAward summary · 100% tuition fees (paid at home rate) and a minimum annual stipend of £19, /2025) with support for research costs. International candidates will be required to fund the difference between the home and international fees. · Overview · Are you interested in learning ...
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NHS Registered Nurse NHS Registered Nurse
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Technical Specialist
Found in: beBee S2 UK - 2 days ago
Newcastle University Newcastle upon Tyne, United Kingdom Full time, Fixed-Term/ContractCompany description: · We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fu ...
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Clinical Research Associate
Found in: Talent UK C2 - 6 days ago
Newcastle University Newcastle upon Tyne, United KingdomSalary: £36,962 to £63,152 per annum (pro rata) · Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. · ...
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Clinical Research Associate
Found in: Talent UK C2 - 5 days ago
Newcastle University Newcastle upon Tyne, United Kingdom Part timeThe Role · We are pleased to advertise a 3-month fixed-term Clinical Research Associate position available for an enthusiastic and highly motivated oncology trainee to complete and in-depth analysis and report of extensive microbiome data in relation to the Monitoring immunE Dys ...
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Senior Research Software Engineer
Found in: beBee S2 UK - 6 days ago
Newcastle University Newcastle upon Tyne, United Kingdom Full time, Fixed-Term/ContractCompany description: · We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fu ...
Research Assistant/Associate in Cancer Research - Newcastle upon Tyne, United Kingdom - Newcastle University
Description
Company description:
We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.
Job description:
Salary:
Research Assistant: £31,396 to £32,982 per annum
Research Associate: £33,966 to £36,024 per annum
The Role
Your role is to take ownership and deliver this proposed and exciting research project within the time limits specified by the JGWP project grant (1 year). You will receive supervision and support from 2 principal investigators based at the Newcastle University Centre for Cancer and have access to the full suite of infrastructure required to successfully complete this project. You will work in the vibrant and stimulating research environment at the Wolfson Childhood Cancer Research Centre. Attendance and presentation of research progress at inter / -national conferences will be strongly encouraged.
Our group has previously shown drug synergy between Dexamethasone and Dasatinib resulting in enhanced activation of the GR transcriptional programme and cell kill. (PMID: We wish to determine the molecular mechanism of drug synergy and exploit this knowledge to reverse Dexamethasone resistance and improve outcomes for patients with ALL/LBL.
We have generated mass spectrometry proteomics data using our in-house developed APEX2-/TurboID peroxidase-directed proximal biotinylation assay. The candidate will analyse our GR interactome proteomics data and identify differential chaperone recruitment to the GR complex in function of selected drug pressure. The functional role of candidate proteins could be validated using a variety of techniques, including chromatin and RNA immunoprecipitation, CRISPR knock-out and/or small molecule inhibitors.
We know that GR can also translocate to mitochondrial DNA and may thus play a role in the observed synergy. This angle has not been explored and you will undertake studies to confirm GR translocation and evaluate GR transcriptional activation in the mitochondria.
Finally, in a parallel project, we are interested to understand the role of the CYLD tumour suppressor in drug resistance. We have acquired 2 CYLD knockout cell lines that will allow the determination of CYLD downstream pathways that play a potential role in drug resistance. Once identified, we aim to explore small molecule inhibition of these pathways to reverse drug resistance.
This full time post is offered on a fixed term basis for a period of 12 Months.
For informal enquiries contact: Dr Frederik W van Delft,
Find out more about the Faculty of Medical Sciences here:
Find out more about our Research Institutes here:
As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.
£31,396 to £36,024 per annum