Primary Pharmacology, Research Biochemist - Oxford, United Kingdom - Lifelancer

Description

The Role

We are expanding our in vitro cell biology capabilities at our new state of the art laboratories in Milton Park and are seeking experienced, motivated, and dynamic individuals to join the primary pharmacology team. This team provides critical data driving our drug discovery projects and is in charge of conceiving, developing, and executing cellular assays for a range of target classes, often in areas of novel biology.

Successful applicants will be given the freedom to design, plan and execute a variety of experiments ensuring that the assays are fit-for-purpose, and that data is appropriately quality-controlled. In our newly built laboratories, we have access to a wide array of assay technologies (FRET, luminescence, FACs, imaging) with automation capabilities and are continually striving to deploy the latest technologies and develop ever more efficient processes.

Please note this is an on-site role at our Milton Park site in Oxford, with occasional flexibility to work from home in the UK. We are a flexible working organisation and were willing to consider other options which would provide similar contact time with the team.

You will have the opportunity to:

Develop, optimise and validate assays to help drive development of therapeutic small molecules with a focus on compound characterisation and the rapid identification of candidate molecules.

You will be expected to keep up with the latest scientific developments, evaluate new technologies and will have the opportunity to present both internally and externally.

This is primarily a laboratory-based positions with scope for continual learning and development and exposure to all scientific disciplines within the drug discovery process from target validation to candidate selection.

Requirements

• BSc/MSc/ Ph.D in Biology, Pharmacology, or a related discipline degree or significant relevant experience, preferably in the pharmaceutical or biotechnology industry.
• Experience of biochemical/biophysical assay techniques for in vitro assay development, optimisation and validation.
• Practical knowledge of a wide range of assay technologies such as FRET, fluorescence polarisation, luminescence assays, thermal shift.
• Experience of screening and data analysis including dose-response relationships.
• Experience of MOA studies to obtain mechanistic data.
• Knowledge of quality control assay statistics to provide high quality data.
• Flexible, adaptable, and able to work across multiple projects.
• Excellent communication skills, both written and verbal, with ability to communicate technical information to a non-specialist audience.

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