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Newcastle University Newcastle, United Kingdom Full timeNewcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. · The role · We are seeking a talented researcher w ...
Protein Engineer - Newcastle upon Tyne, United Kingdom - Hlx Life Sciences
Description
We are working in partnership with a start-up biotech firm, supporting them in the growth of their scientific team. This role is full-time and requires on-site presence for five days a week.Test, screen, and produce soluble TCR-based therapeutics for clinical development using cutting-edge molecular biology techniques, protein engineering methodologies, and structural biology approaches.
# Sequence analyses of the library outputs.Collaboratively work with the Biology and CMC teams to guide optimization and development of soluble TCRs. Design and conduct experimental work to align with Company priorities and meet scientific timelines, report results succinctly and effectively. Provide oversight of specific elements within a project or projects and supervise other scientists. A PhD in a relevant biological subject alongside some postdoctoral experience and/or experience in the biotech/pharma industry.
Direct hands-on laboratory experience in developing high affinity antibodies or soluble TCR molecules using molecular evolution approach (phage display, yeast display etc.).
Strong proven expertise in molecular biology and protein engineering techniques, including rational design, phage display, library construction, affinity maturation approaches, site-directed mutagenesis, cloning.
Experience in screening affinity maturation outputs and candidate molecules through techniques such as ELISA, DNA sequence analyses etc. Experience in analyses of protein affinity and cross-reactivity using SPR/Biacore. Inclusive, collaborative, and thrives in a team environment with a flexible approach to working. Demonstrable problem-solving ability, creative thinking, and be proactive in driving the project forwards.#
