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    R&D Scientist/Engineer - Slough, Berkshire, United Kingdom - SRG

    SRG
    SRG Slough, Berkshire, United Kingdom

    2 weeks ago

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    Description

    Job Title:
    Senior/Research Scientist – Mass spec Contract: 12 months


    Location:
    Slough


    Salary:
    £28.09 – 33.58 PAYE, £38.24 Umbrella

    SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team.

    This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.


    Key Responsibilities will include:

    and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.

    track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.

    and prioritise the demands from multiple projects.


    Essential Requirements:

    or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.

    with Waters data processing software packages (PLGS) and DynamXTM.
    knowledge Waters HDX-MS system.
    of structural visualisation tools (PyMOL, Chimera or similar).
    with HDX-MS experiments using NBE and NCE molecules.
    organisational, communication, record keeping and team-working abilities.


    Desirable Requirements:
    analysis of membrane proteins.
    and maintenance of Waters LC/MS equipment.
    ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
    track record of publications related to mass spectrometry in peer reviewed journals.
    of recombinant protein expression systems and PTMs.
    knowledge of Thermo Scientific Orbitrap MS systems.
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