Quotient Therapeutics, Inc. - United Kingdom - Flagship Pioneering

Description

What if... you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?

Company Summary:
Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreakingcompanies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA) Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Position Summary:

• Contribute to statistical genetics efforts to leverage population genetics in the setting of a novel genomics platform to gain and integrate insights into complex disease biology across multiple different therapeutic areas to successfully drive programs in support of the discovery platform.

Responsibilities:

• Analyse large-scale genomic data including UKBB, Genomics England, and usage of the GWAS catalog and OpenTargets to derive population genetics insights into diseases and traits of interest
• Apply statistical methodology and develop novel analytical approaches to analyse high-dimensional genomic data (GWAS, WES, WGS, transcriptomics, proteomics, etc.) across multiple disease areas
• Work with computational colleagues to integrate germline genetics datasets with somatic genetics datasets and other modalities including bulk RNAseq, scRNA seq, and other more novel modalities
• Use Mendelian randomization to elucidate causal mechanisms, pathway information and other functional data to prioritize effector genes and causal mechanisms and information across multiple traits or variants to generate insights
• Participate in the design and implementation of cutting-edge genetic studies and analysis strategies, and identify potential problems and propose remedies or refinements
• Stay up-to-date with the latest advancements in statistical genetics and contribute to the development of new research strategies and methodologies

Qualifications:

• PhD in Quantitative genomics, Statistics, Computational Biology, or related fields
• Strong background in genomics and experience in next-generation sequencing (NGS) data analysis
• Strong analytical and problem-solving skills, with the ability to develop and implement novel computational approaches
• Proficiency in statistical programming languages such a R or Python
• Ability to work on multiple projects simultaneously and prioritise tasks
• Ability to work both independently and collaboratively in a team-oriented, fast-paced environment
• Excellent oral and written communication skills, both written and verbal, with the ability to convey complex scientific concepts clearly and concisely

Preferred Attributes:

• Previous experience working in the pharmaceutical industry is desirable for this role
• Experience with database query work, particularly in the context of genomic datasets

Location: Cambridge, England

Company Summary:
Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA) Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Position Summary:

We are seeking a motivated, enthusiastic Research Associate in Molecular Biology to join our passionate team of scientists. The candidates will work closely with scientists to advance multiple aspects of our R&D programs at Quotient Therapeutics. The successful candidate will be a self-starter, able to thrive in a fast-paced, action-oriented team environment with a clear passion for science and impact. The individual will have demonstrated evidence of agility and nimbleness to progress scientific discoveries, and an overt attitude of positivity when facing challenges. The candidate will be dedicated to develop and grow outside their comfort zone by constantly learning.

Key Responsibilities:

• Drive scientific and R&D efforts by conducting experiments alongside Scientists in the laboratory
• Support the implementation of novel target discovery platforms, protocols, and other assays
• Collaborate and communicate with other team members across various functional areas

Key Skills and Experiences:

• BS or MS degree in biochemistry, molecular or micro biology, or related field
• Minimum BS and relevant experience. Will consider hiring at the Sr. RA level for candidates with MS and/or demonstratable relevant experience.
• Hands on experience in, histology processes, DNA handling and PCR are required
• Experience or interest in a variety of molecular biology and biochemistry techniques: including DNA extraction, NGS library preparation, tissue sectioning and LCM, are highly preferred.
• Experience in Immunology, mRNA expression analysis, DNA/RNA purification, or RNA biology, gene therapy or editing and NGS are also preferred

Join Our Innovative Biotech Venture:

At Quotient Therapeutics, we're not just a team; we're pioneers on a mission to revolutionise the biotech landscape. Nestled in the vibrant outskirts of Cambridge, our company is all about innovative thinking and collaborative spirit.

What We Offer:

• A Crucible of Innovation : Dive into a world where your ideas matter. Our work environment is dynamic, encouraging creativity and out-of-the-box thinking. Here, every voice contributes to our groundbreaking solutions.
• Professional Growth in a Supportive Environment : While we're small, our aspirations are big. You'll have the unique opportunity to grow with us, learning new skills and tackling diverse challenges every day. Your growth is our growth.
• Competitive Compensation : We understand the value of our team. That's why we offer competitive salaries that match your expertise and contribution to our shared goals.
• Above Standard Facilities : Our labs and workspaces are more than just functional. Enjoy working in above-standard facilities that stand out in the start-up world, fostering both comfort and innovation.
• Located at the Heart of Biotech Innovation : Our location isn't just a place; it's a strategic advantage. Situated near Cambridge, you'll be at the crossroads of biotech innovation and a thriving, intellectually stimulating community.
• Making a Difference : Here, your work transcends the ordinary. We're about making a tangible, positive impact on the world through our biotech advancements.
• Equality, Diversity, and Inclusion Aware : We're committed to creating a workplace where everyone feels valued and respected. While our formal ED&I statement is still in the works, we're actively aware and integrating these principles into our daily operations.
• While we are still growing and enhancing our benefits package, we believe that the opportunity to be a part of a transformative team in a rapidly evolving industry is a rewarding experience in itself. If you're ready to make a significant impact and grow with us, we'd love to hear from you.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.