- A Ph.D. in chemistry, chemical biology, biochemistry, structural biology, drug discovery or a related discipline
- 4+ years of relevant experience in modern approaches to small-molecule drug discovery and development.
- Outstanding academic and/or industrial track record. Excellent interpersonal, communication and presentation skills.
- Capable of working in a diverse team, but able to plan and work independently.
- Exceptional time management, organisational and self-motivational skills.
- An open and collaborative approach to science.
- Background in academic or industrial drug discovery along with demonstrated track record of project leadership and management roles are strongly desirable.
- Experience with studying of PROTACs and/or molecular glue degraders.
- Experience with drug discovery approaches to hit identification, development and lead optimization.
-
Data Team Lead
2 days ago
NetTalent Scotland, United Kingdom**Location**: Glasgow, Scotland - Hybrid / Remote · **Company Insight**: · Net Talent are partnered with one of Glasgow's best success stories who specialise in global facilities management, to help source a talented Data Team Lead with Power BI experience to provide ongoing supp ...
-
QA Officer
6 days ago
Hyper Recruitment Solutions Ltd Scotland, United KingdomWe are currently looking for a QA Officer to join a leading Bio-pharmaceutical company based in the Scotland area. As the QA Officer you will be responsible for; · KEY DUTIES AND RESPONSIBILITIES: · Your duties as the QA Officer will be varied however the key duties and responsib ...
-
Industrial Post Doc
1 week ago
Havas People Scotland, United KingdomPosition 2– Chemical Biology / Screening Assay Development PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with exp ...
-
KOODAC Team Chemical Biologist
1 week ago
Havas People Scotland, United KingdomPosition 2– Chemical Biology / Screening Assay Development PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Chemical Biologist / Biophysical Chemist with exp ...
-
Senior Officer, Planning
12 hours ago
CRUK Scotland Institute Scotland, United KingdomEmployer CRUK Scotland Institute Location Glasgow City (GB) Salary Range: £25,767 to £43,197 depending on experience Closing date 14 Jun 2024 · The CRUK Scotland Institute is a cancer research institute, situated in Glasgow with approximately 250 researchers split across 30 rese ...
-
Senior Scientific Officer
12 hours ago
CRUK Scotland Institute Scotland, United KingdomEmployer CRUK Scotland Institute Location Glasgow City (GB) Salary Range: £25,767 to £43,197 depending on experience Closing date 14 Jun 2024 · Transgenic Technologies – Dr Douglas Strathdee · About us · The CRUK Scotland Institute is a cancer research institute, situated in G ...
-
Advanced Healthcare Scientist
1 week ago
NHS National Services Scotland Scotland, United Kingdom PermanentAdvanced Healthcare Scientist (Epidemiology) · About the Organisation: · National Services Scotland (NSS) is a national NHS Board operating right at the heart of NHSScotland providing invaluable support and advice at a strategic and operational level. NSS supports customers t ...
-
Experience Consultant
1 week ago
NHS Fife Scotland, United KingdomApplications are invited for a Consultant Pathologist post within the Department of Cellular Pathology, Victoria Hospital, Kirkcaldy. This is a full time replacement post to join a team of 7 other pathologists within a busy District General Hospital Department. Participation in t ...
-
Biologist I
1 week ago
Havas People Scotland, United KingdomPosition 3 – Structural Biology / Biophysical Assay Development PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · Alessio Ciulli as a Postdoctoral Research Assistant within the expanding Centre f ...
-
Training & Quality Consultant
2 days ago
NHS Fife Scotland, United KingdomNHS Scotland is committed to encouraging equality and diversity among our workforce and eliminating unlawful discrimination. To this end, NHS Scotlandwelcomes applications from all sections of society. · Applications are invited for a Consultant Pathologist post within the Depar ...
-
Business Assistant
2 days ago
Project People Scotland, United KingdomJob title : Business Assistant - Mandarin speaking · Location : Edinburgh · Our client, a leading telecommunications company is looking for a well-organised individual to support its Edinburgh branch. · What you will do: · Personal assistant to lab director and lab chief sc ...
-
KOODAC Team Structural Biologist
1 week ago
Havas People Scotland, United KingdomPosition 3 – Structural Biology / Biophysical Assay Development PDRA (KOODAC team) · Unit: Centre for Targeted Protein Degradation Fixed-Term for 5 years · Grade 7 (Spinal Point £36,024- £44,263) · We are recruiting for an exceptional Structural Biologist / Biophysicist with exp ...
-
Student Inclusion Co-Ordinator
2 days ago
CRUK Scotland Institute Scotland, United KingdomResearch Funding Co-ordinator · Salary: Competitive salary (depending on experience) · Contract term: Permanent position · The CRUK Scotland Institute is a cancer research institute situated in Glasgow with approximately 250 researchers split across 30 research groups consistin ...
-
Freshwater Adviser
1 week ago
NatureScot Scotland, United Kingdom Full timeJob Purpose Summary · The successful candidate for this role will join the Freshwater and Wetlands Group (FWWG) as the river habitat lead. The group has national responsibility for advice, reporting and policy development in freshwaters. This is a re-advertisement externally, hav ...
-
ECO Magazine Scotland, United KingdomOcean Career: Head of Skills and Talent at Sustainable Aquaculture Innovation Centre · The Sustainable Aquaculture Innovation Centre (SAIC) works to increase the economic impact and reduce the environmental footprint of aquaculture. Connecting businesses and academics, we fund a ...
-
National Account Manager
2 days ago
Abbott Laboratories Scotland, United KingdomKey Account Manager - Rapid Diagnostics (Scotland) page is loaded Key Account Manager - Rapid Diagnostics (Scotland) · Apply locations Scotland United Kingdom-Dundee United Kingdom-Aberdeen United Kingdom-Glasgow United Kingdom-Edinburgh time type Full time posted on Posted 11 Da ...
KOODAC Team Senior Lead Scientist - Scotland, United Kingdom - Havas People
Description
Position 1 - Senior Lead Scientist: Chemical Structural Biology / Medicinal Chemistry (KOODAC team) Unit: Centre for Targeted Protein Degradation
Fixed-Term for 5 years
Grade 8 (Spinal Point £45,585- £54,395)
We are recruiting for an exceptional individual with expertise in Chemical Structural Biology and/or Medicinal Chemistry applied to Drug Discovery to join the group of Professor Alessio Ciulli as a Senior Lead Scientist within the expanding Centre for Targeted Protein Degradation (CeTPD) at the University of Dundee. This position is part of an academic, multi- disciplinary drug discovery team being formed within the Ciulli group, funded by the Cancer Grand Challenges, within KOODAC ( . KOODAC's mission is to discover and develop small- molecule drugs that degrade key oncogenic drivers of solid tumours in children , as a novel therapeutic paradigm to treat pediatric cancers. The team will develop two types of degraders – proteolysis targeting chimeras (PROTACs) and molecular glues. Both classes of degraders work by recruiting a ubiquitin E3 ligase to a target protein to induce target's ubiquitination and degradation, leading to cell death. The team will focus on developing degraders for the ALK, DNAJB1::PRKACA, MYCN, EWSR1::FLI1 and PAX3::FOXO1 (or PAX7::FOXO1) oncoproteins, which have been implicated in the development and/or spread of neuroblastoma, fibrolamellar hepatocellular carcinoma, medulloblastoma, Ewings sarcoma and fusion positive rhabdomyosarcoma, respectively, in children. The successful candidate will be expected to pioneer the design, develop and implement the CeTPD team's range of chemical structural biology and medicinal chemistry approaches to discover and optimize small-molecule degraders across the collaboration project targets, with a focus on high-throughput chemistry coupled with biophysics-driven structure-based drug design. You will be expected to be approximately 2/3 of time based in the laboratory. In addition to lab work, you will be responsible for the day-to-day project leadership, data management, and resource management. You will work closely with the PI (Prof. Ciulli) to contribute to various aspects of team building, from scientific excellence to fostering a collaborative open team's culture. You will also work very closely with the other PDRAs within the team in the Ciulli Lab, as well as scientists at our collaborating partners within KOODAC.
Candidate Requirements:
Preferred skills:
The position is available immediately and for a fixed-term of 5 years. For further information about this role contact Professor Alessio Ciulli at To find out more about Group please visit the group's Website.
The Centre for Targeted Protein Degradation is part of a growing Life Sciences Innovation District, an ecosystem of organisations and people within the life sciences sector in Dundee driving innovation and local economic growth. Opened since January 2023, CeTPD is a first of its kind Centre leading a number of internationally significant projects in the burgeoning new area of translational chemical biology and targeted protein degradation. The goal of CeTPD is to innovate a next-generation of small-molecule technology platforms and modalities to advance chemical and biological insights and therapeutic targets related to human diseases. It aspires to achieve this by redefining new models of open collaboration with academic, industrial and venture partners, and by training and inspiring the next-generation of research scientists and leaders.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for
undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.
#J-18808-Ljbffr
