Investigator – Cell Culture Patient Derived Organoid - Stevenage, United Kingdom - Workday

Description

Investigator – Cell Culture Patient Derived Organoid

We are looking for a highly motivated scientist with experience in organoid development and oncology cellular biology to join the Oncology Translational Research team within GSK Oncology TA. The Oncology Translational Research team will partner with Oncology TA team members increase clinical translatability and to contribute to preclinical development programmes within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting patient-derived organoids, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

Key responsibilities

• Setting up cell culture protocols to grow and expand patient-derived organoids upon reception.
• Oversight and performing the cell culture/ expansion.
• Performing patient-derived organoids quality control steps (cell density, proliferation rate and cytotoxicity evaluation).
• Setting up and performing multimodality experiments according to the DBT lab project (cell plating, treatment, and organoids coculture with immune cells).
• Collecting and reporting data to the lab head.
• Executing and delivering of the project.
• Solving technical issue operate as part of a cross-functional project team.
• Collaborating/cooperating with KCL scientists within the GSK-KCL Translational Oncology Research Hub, an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

Closing Date for Applications: 15th December 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above.

The information that you have provided in your cover letter and CV will be used to assess your application.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• BSc in Cell Biology/Oncology or related
• A multidisciplinary mix of training/expertise in Oncology and Cancer cell biology.
• Significant experience in cell culture techniques (primary samples/ patient-derived organoids), cytotoxicity analysis.
• Cellular and molecular Biology skills: cell isolation from human biopsies/samples; culture of normal and tumor cells from primary samples or immortalized cell lines; cell isolation from buffy coats; organoid establishment from fresh or frozen tissue; 3D culture in Matrigel or scaffolds (spheroids and organoids)
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude

Preferred Qualifications

If you have the following characteristics, it would be a plus:

• MSc or PhD in Cell Biology/Oncology or related
• Background of immunology
• Experience in flow cytometry
• A track record of scientific Publication
• Experience in collaboration with biopharma

Why Us?

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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